泡扩大了水生环境中抗生素耐药性的传播
Jian-Lu Duan1, Jing-Ya Ma1, Xiao-Dong Sun1
1Shandong Key Laboratory of Environmental Processes and Health, School of Environmental Science and Engineering, Shandong University, Qingdao, Shandong 266237, P. R. China.
Environmental science & technology
|June 28, 2023
概括
气泡可以通过喷射抗生素耐药细菌 (ARB) 通过空气传播它们并形成生物膜. 气泡诱导的水滴与细菌细胞外基质 (ECM) 之间的相互作用推动了这种空气传播.
科学领域:
- 环境微生物学环境微生物学
- 航空生物学 航空生物学
- 细菌生理学 细菌生理学
背景情况:
- 抗生素耐药性是一个关键的全球健康威胁,由COVID-19大流行加剧.
- 抗生素耐药细菌 (ARB) 在空气中传播是一个重大问题.
- 泡破裂是已知的粒子生成机制,但其在ARB传播中的作用尚未被证明.
研究的目的:
- 研究气泡在促进抗生素耐药细菌在空气中传播方面的潜力.
- 阐明气泡与ARB相互作用并促进基因转移的机制.
- 了解细菌细胞外矩阵 (ECM) 在泡介导的ARB传播中的作用.
主要方法:
- 实验观察细菌充满的泡破裂.
- 原子力显微镜 (AFM) 使用单泡探头.
- 分子动力学 (MD) 模拟.分子动力学 (MD) 模拟.
- 在空气-液体界面的细菌生物膜形成的分析.
主要成果:
- 气泡有效地将丰富的细菌喷射到空气中.
- 稳定的细菌生物膜在空气-水界面形成,促进细胞-细胞接触和水平基因转移.
- 细菌ECM,特别是多糖,增强了泡的附着和寿命,导致滴滴的产生增加.
- 气泡表面和细菌ECM之间的疏水性相互作用决定了气泡-细菌的粘附.
结论:
- 气泡在抗生素耐药细菌在空气中传播方面发挥着重要作用.
- 气泡和细菌ECM之间的物理化学相互作用对于有效的ARB传播至关重要.
- 这项研究为了解通过泡介导的抗生素耐药性传播提供了一个框架.
相关概念视频
00:57Antibiotic Selection
54.8K
Overview
54.8K
01:30Development of Antibiotic Resistance
46
Antibiotic resistance is a major public health concern that arises when bacteria evolve mechanisms to withstand the effects of antibiotic treatments. This resistance can be intrinsic, acquired through genetic mutations, or transferred between bacteria via horizontal gene transfer. The development of antibiotic resistance poses significant challenges in treating bacterial infections and necessitates ongoing research to develop new therapeutic strategies.Intrinsic resistance occurs when bacterial...
46
01:28Gene Regulation in Microbial Communities: Quorum Sensing
49
Quorum sensing is a mechanism of bacterial communication that enables coordinated gene expression in response to changes in population density. This facilitates collective behaviors that enhance survival, resource acquisition, and ecological adaptation. This process relies on small signaling molecules called autoinducers that accumulate as bacterial populations grow. When a critical threshold concentration of autoinducers is reached, bacterial cells collectively modify gene expression,...
49
01:28Antimicrobial Effectiveness
98
The effectiveness of antimicrobial agents depends on various factors influencing their ability to eliminate microbial populations. Larger microbial populations require more time for complete eradication, emphasizing the importance of population size analysis when evaluating antimicrobial efficacy.Microbial resistance to antimicrobial agents varies significantly. Highly resilient microorganisms include endospores, gram-negative bacteria, and non-enveloped viruses, while prions are exceptionally...
98
01:30Bacterial Signaling
32.9K
Bacterial signaling can occur within bacteria (intracellular) or between bacteria (intercellular). At times, a group of bacteria behaves like a community. To achieve this, they engage in quorum sensing, the perception of higher cell density that causes changes in gene expression. Quorum sensing involves both extracellular and intracellular signaling. The signaling cascade starts with a molecule called an autoinducer (AI). Individual bacteria produce AIs that move out of the bacterial cell...
32.9K
01:18Surface Membrane Barriers
1.2K
The skin and mucous membranes serve as the primary line of defense against pathogens by providing both physical and chemical protection. These barriers are essential in preventing the entry and establishment of microbes, thereby maintaining the integrity of the host.
The outer layer of the skin, the epidermis, is a robust barrier comprising layers of closely packed keratinized cells. This dense arrangement prevents microbes from penetrating the body. The periodic shedding of epidermal cells...
The outer layer of the skin, the epidermis, is a robust barrier comprising layers of closely packed keratinized cells. This dense arrangement prevents microbes from penetrating the body. The periodic shedding of epidermal cells...
1.2K