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基于机器学习的对心脏放松障碍的分类,使用了sarcomere长度和细胞内过渡物
Rana Raza Mehdi1, Mohit Kumar2, Emilio A Mendiola1
1Department of Biomedical Engineering, Texas A&M University, College Station, TX 77843, USA.
Computers in biology and medicine
|June 28, 2023
概括
机器学习模型现在可以使用 sarcomere 和数据对正常与受损的心肌细胞放松进行分类. 一个软投票分类器实现了高准确度,识别了区分细胞功能的关键特征.
科学领域:
- 心血管生理学心血管生理学
- 计算生物学 计算生物学
- 生物医学工程 生物医学工程
背景情况:
- 左心室的舒张功能障碍源于心肌细胞放松受损.
- 放松速度受到细胞内 (Ca2+) 循环动态的影响.
- 需要一种计算工具来根据放松动力学来区分正常细胞和受损细胞.
研究的目的:
- 开发和评估用于区分正常和受损心肌细胞的机器学习分类器.
- 为了利用瘤长度和细胞内过渡数据进行分类.
- 确定最有效的分类器和相关特征,以预测心肌细胞放松障碍.
主要方法:
- 从野生类型 (正常) 和转基因 (受损) 鼠心肌细胞中获得了沙科梅尔动力学和细胞内动力学的活体测量.
- 训练了九种不同的机器学习分类器,并使用对sarcomere长度短暂和短暂数据集的交叉验证进行了评估.
- 进行了层级相关性传播 (LRP) 分析,以确定重要的预测特征.
主要成果:
- 一个软投票分类器表现出卓越的性能,在接收器操作特征曲线下的面积为0.94对于长度数据和0.95对于数据.
- 多层感知子分类器获得了相似的高分,而决策树和极端梯度增强性能则随特征集而变化.
- LRP分析确定了50%收缩 (sarcomere) 和50%衰变 (calcium) 的时间是高度相关的特征.
结论:
- 机器学习,特别是软投票分类器,可以准确地使用sarcomere和动力学来分类心肌细胞放松状态.
- 这项研究强调了特征选择和分类器选择对于准确预测透支功能障碍的重要性.
- 开发的算法显示了在未知样本中对心肌细胞放松行为进行分类的潜力.
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