复发性口腔口腔口腔炎的活跃和被动状态中的口腔微生物群:对病例控制研究的分析
Xuan Xiao1, Zhaocheng Shi1, Yuhan Song1
1Department of Oral Mucosa, Shanghai Stomatological Hospital & School of Stomatology, Fudan University, Shanghai, China; Shanghai Key Laboratory of Craniomaxillofacial Development and Diseases, Fudan University, Shanghai, China.
Archives of oral biology
|June 28, 2023
概括
复发性口腔炎 (RAS) 病变中的微生物群落与健康对照群不同. 这些微生物的转变,而不是单一的病原体,可能会通过改变免疫反应或损害口腔组织来推动RAS的发展.
科学领域:
- 口腔微生物学 口腔微生物学
- 免疫皮肤学 免疫皮肤学
- 微生物组研究的研究.
背景情况:
- 复发性口腔口腔炎 (RAS) 是一种常见的口腔疾病,病因不明.
- 以前的研究表明,微生物因素在RAS病变发生过程中起着作用.
- 了解RAS中的口腔微生物群对于开发向疗法至关重要.
研究的目的:
- 为了确定与健康对照相比,在复发性口腔口炎 (RAS) 病变中明显的微生物患病率.
- 分析与RAS的活性和被动状态相关的细菌的组成和丰度.
- 阐明微生物失生症在口腔的发展中的潜在作用.
主要方法:
- 在2022年11月之前对病例控制研究进行系统审查和元分析.
- 包括14项研究,包括531例活跃RAS病例,92例被动RAS病例和372例健康对照.
- 通过粘膜拭子,活检,微刷和唾液获得的微生物样本的分析.
主要成果:
- 与健康对照人群相比,在RAS病变中观察到细菌丰度的显著变化.
- 多种细菌物种在RAS的活性和被动状态中都显示出变化的流行率.
- 在患有复发性口腔口腔炎的个体中,口腔微生物组的组成明显不同.
结论:
- RAS的病因可能是多因素的,涉及复杂的微生物相互作用,而不是单一的致病剂.
- 微生物失生症可能通过调节宿主免疫反应来促进RAS.
- 口腔微生物组的改变可能会损害上皮质的完整性,促进RAS中的形成.
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