相关实验视频
Updated: Jul 25, 2025
06:58
Physiology Lab Demonstration: Glomerular Filtration Rate in a Rat
Published on: July 26, 2015
17.4K
对比老年人膜过率估计方程:系统性审查和元分析
Yao Ma1, Xue Shen1, Zhenzhu Yong1
1Division of Nephrology, Department of Geriatrics, Jiangsu Province Hospital and Nanjing Medical University First Affiliated Hospital, Nanjing 210029, Jiangsu, China.
Archives of gerontology and geriatrics
|June 28, 2023
概括
与CKD-EPI相比,像BIS和FAS这样的新方程式在老年人中提供了更准确的膜过率 (GFR) 估计. 完整年龄谱 (FAS) 方程适用于大多数疾病,而CKD-EPICr-Cys最适合功能受损.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 老年医学 老年医学
- 临床化学 临床化学
背景情况:
- 在老年人中,精确估计膜过率 (GFR) 是至关重要的,但具有挑战性.
- 现有的GFR估计方程显示了老年人群的可变性能.
- 本元分析评估了60岁及以上个体中六种常见的GFR方程.
研究的目的:
- 在老年人中比较六种常用的GFR估计方程的准确性和偏差.
- 为了评估CKD-EPICr,CKD-EPICr-Cys,BIS1,BIS2,FASCr,以及FASCr-Cys的性能.
- 为老年人群确定最可靠的GFR方程.
主要方法:
- 对27项涉及18112名参与者的研究进行了元分析.
- 估计的GFR (eGFR) 值与测量的GFR (mGFR) 值进行了比较.
- 使用P30 (在mGFR的30%以内估计的百分比) 和偏差来评估性能,并根据年龄,种族和GFR水平对子组进行分析.
主要成果:
- 在BIS1和FASCr中,P30显著高于CKD-EPICr.
- 在FASCr和BIS1之间,或在组合方程 (CKD-EPICr-Cys,BIS2,FASCr-Cys) 之间,没有发现P30或偏差的显著差异.
- 总体而言,FASCr和FASCr-Cys的表现更好,但CKD-EPICr-Cys在mGFR<45mL/min/1.73m2>的个体中表现出更高的P30和更低的偏差.
结论:
- 柏林倡议研究 (BIS) 和全年谱 (FAS) 方程与慢性病流行病学协作 (CKD-EPI) 方程相比,在老年人中提供更准确的GFR估计.
- 建议在老年人群中一般使用FASCr和FASCr-Cys.
- CKD-EPICr-Cys是显著功能受损的老年人 (mGFR < 45mL/min/1.73m2) 的首选选择.
相关概念视频
01:17Factors Affecting Renal Clearance: Renal Impairment
123
Renal dysfunction significantly impairs the renal clearance of drugs, leading to potential complications in drug therapy. Renal failure, which can be caused by various factors, poses a significant challenge in the elimination of drugs from the body.
One condition associated with renal failure is uremia. Uremia is characterized by impaired glomerular filtration and fluid accumulation in the body. This condition hinders the renal clearance of drugs, resulting in drug accumulation and potential...
One condition associated with renal failure is uremia. Uremia is characterized by impaired glomerular filtration and fluid accumulation in the body. This condition hinders the renal clearance of drugs, resulting in drug accumulation and potential...
123
01:28Glomerular Filtration Rate and its Regulation
3.0K
The Glomerular Filtration Rate (GFR) is a measure of kidney function, reflecting the volume of filtrate formed per minute in the kidneys. On average, GFR is approximately 125 mL/min in males and 105 mL/min in females. Maintaining a relatively constant GFR is essential for the kidneys to effectively regulate body fluid homeostasis and maintain extracellular stability.
GFR regulation involves two primary intrinsic controls: the myogenic and tubuloglomerular feedback mechanisms.
The myogenic...
GFR regulation involves two primary intrinsic controls: the myogenic and tubuloglomerular feedback mechanisms.
The myogenic...
3.0K
01:02Renal Drug Excretion: Glomerular Filtration
331
The kidney serves as the primary organ responsible for eliminating drugs and their metabolites from the body. This process, known as renal elimination, starts with glomerular filtration and results in urine formation. Each kidney houses millions of functional units called nephrons, where urine production occurs. A nephron has two main components: a renal corpuscle and a renal tubule.
Drugs gain access to the kidney via the renal artery, which progressively branches off into afferent arterioles....
Drugs gain access to the kidney via the renal artery, which progressively branches off into afferent arterioles....
331
01:08Renal Drug Clearance: Comparison Between Renal Excretion Methods
184
Renal clearance is a critical parameter encompassing kidney filtration, secretion, and reabsorption processes. It is calculated using a specific equation to determine the rate at which the kidneys clear a drug.
Renal clearance is often associated with the renal glomerular filtration rate (GFR), which represents the rate at which plasma is filtered through the glomeruli in the kidney. When drug reabsorption is minimal and there is no active secretion, renal clearance is closely related to the...
Renal clearance is often associated with the renal glomerular filtration rate (GFR), which represents the rate at which plasma is filtered through the glomeruli in the kidney. When drug reabsorption is minimal and there is no active secretion, renal clearance is closely related to the...
184
01:24Serum Studies: Renal Function Tests
24
Renal function tests are crucial for assessing kidney health, monitoring disease progression, and evaluating the kidneys' efficiency in waste elimination, fluid balance, and electrolyte regulation. These tests offer critical insights into kidney function, even though routine measurements may appear normal until there is a significant decline in the glomerular filtration rate or GFR. Typically, signs of kidney impairment only become evident when the GFR falls to about 50% of its normal level.
24
01:23Renal Clearance
1.1K
The glomerular filtration rate (GFR) is a critical marker of kidney function, reflecting the efficiency of filtration by the glomeruli. Renal clearance of specific substances, such as inulin or creatinine, is commonly used to measure GFR.
Renal clearance refers to the volume of plasma cleared of a specific substance, such as creatinine, per unit of time. To measure clearance, urine samples are collected over a 24-hour period during each bladder voiding, followed by a single blood sample at the...
Renal clearance refers to the volume of plasma cleared of a specific substance, such as creatinine, per unit of time. To measure clearance, urine samples are collected over a 24-hour period during each bladder voiding, followed by a single blood sample at the...
1.1K