INFN质子计算机断层扫描系统用于相对制动功率测量:校准和验证
Monica Scaringella1, Mara Bruzzi1,2, Paolo Farace3,4
1Istituto Nazionale di Fisica Nucleare sezione di Firenze, Via G. Sansone 1, Sesto Fiorentino (Fi), Italy.
Physics in medicine and biology
|June 28, 2023
概括
这项研究对意大利国家核物理研究所 (INFN) 的质子计算机断层扫描 (pCT) 系统进行了校准,实现了相对于水 (SPR) 地图的质子阻力精度低于1%的精度. 经过验证的校准确保了关键应用的精确3D成像.
科学领域:
- 医学物理 医学物理
- 粒子成像技术 粒子成像技术
- 放射学仪器仪器仪器仪器仪器仪器仪器仪器仪器仪器仪器仪器仪器
背景情况:
- 质子计算机断层扫描 (pCT) 系统需要精确的校准,以获得准确的3D成像.
- 与水相对的质子停止功率 (SPR) 地图对于质子疗法等应用至关重要.
- 国家核物理研究所 (INFN) 开发了一种使用追踪器和YAG:Ce热量计的pCT系统.
研究的目的:
- 描述和验证INFN的3D pCT系统的校准程序.
- 为了实现SPR地图的测量精度和可重复性低于1%.
- 评估校准对图像统一性和工件减少的影响.
主要方法:
- 使用能量从83到210 MeV的质子进行校准.
- 实现位置依赖校准,以实现均的热量计能量响应.
- 开发用于能源重建和纠正器材材料中的能量损失的算法.
- 使用两次单独的数据采集会议中成像的水幻象进行验证.
主要成果:
- 在196.5 MeV时,达到约0.9%的热量计能量分辨率.
- 在对照幻象中测量了0.995±0.002的平均水SPR值.
- 图像不均性始终低于1%.
- 在数据采集会议之间,SPR和统一性值没有显著变化,证实了可重现性.
结论:
- 对于INFN pCT系统的校准程序实现了高精度和可重复性 (<1%).
- 统一的能量响应将图像工件最小化,即使有热量计细分和跟踪器材料变化.
- 经过验证的校准技术使高精度的SPR 3D地图生成为苛刻的应用程序.
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