渐进的斑点血管密度下降和视野进展在开放角眼睛中眼镜眼睛中部视野损伤
Anna Lee1, Ko Eun Kim1, Woo Keun Song1
1Department of Ophthalmology, College of Medicine, Asan Medical Center, University of Ulsan, Seoul, South Korea.
Ophthalmology. Glaucoma
|June 28, 2023
概括
黄斑血管密度 (mVD) 的逐渐丧失与视野 (VF) 在开角玻璃眼 (OAG) 患者的恶化有关. 这种关联适用于与中部VF损伤的眼光病的所有阶段.
科学领域:
- 眼科医生 眼科 眼科
- 玻璃眼研究研究 玻璃眼研究
- 光学连贯性断层扫描血管学
背景情况:
- 开角光眼 (OAG) 是不可逆转失明的主要原因.
- 了解视野 (VF) 损失的进展对于管理OAG至关重要.
- 斑点的结构和血管变化可能会在VF损伤之前或伴随着VF损伤.
研究的目的:
- 为了研究黄斑血管密度 (mVD) 的纵向变化与黄斑结节细胞内形层厚度 (mGCIPLT) 和OAG患者的VF进展之间的关联.
- 分析这些关联在患者中与中央视野 (CVF) 损伤在不同的玻璃眼病阶段 (早期到中度和高级).
主要方法:
- 对223个OAG眼睛进行了回顾性纵向研究,其中基线CVF损失.
- 使用OCT血管造影和OCT测量连续mVD和mGCIPLT,平均随访时间为3.5年.
- 使用基于事件和趋势的分析来评估VF进展;采用线性混合效应和后勤回归模型.
主要成果:
- 在早期至中度青光瘤中,与非进展者相比,进展者显示的mGCIPLT和mVD损失率明显更快.
- 在晚期玻璃眼瘤中,只有mVD损失率在进展者中明显更快.
- 较快的mVD损失预测了VF的进展,不管是青光眼的阶段,而mGCIPLT损失预测的进展仅在早期到中度阶段.
结论:
- 渐进的斑点血管密度损失是OAG患者中视野进展的重要预测因素.
- 这种mVD损失和VF进展之间的关联在不同的玻璃眼病阶段是一致的.
- 斑点血管变化是监测青光眼进展的关键指标.
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