生 (Zingiber officinale Roscoe) 制剂用于术后恶心和吐的预防:贝叶斯网络的元分析
Chunyang Zhao1, Weiyuan Chen2, Daqiu Wang3
1School of Pharmacy, China Medical University, Shenyang, 110122, China; Department of Pharmacy, The First Affiliated Hospital of China Medical University, Shenyang, 110001, China.
Journal of ethnopharmacology
|June 28, 2023
概括
生油有望预防术后吐,但减少术后恶心的证据不太清楚. 需要进一步的研究来确定PONV预防的最佳生制剂.
科学领域:
- 麻醉学和外科手术期间的医学.
- 补充和替代医学 补充和替代医学
- 药理学 药理学是指药理学的学科.
背景情况:
- 手术后恶心和吐 (PONV) 是一个常见的并发症.
- 正在探索PONV预防,但最佳的准备仍然不清楚.
- 关于生在PONV预防中的有效性的证据是模两可的.
研究的目的:
- 进行网络元分析 (NMA),比较用于PONV控制的生制剂.
- 为了对不同生疗法的相对疗效进行排名.
- 为了确定PONV预防的最佳生制剂.
主要方法:
- 从多个数据库 (Medline,Embase,Web of Science等) 系统地检索随机对照试验 (RCT). ) 的情况.
- 使用随机效应模型进行贝叶斯网络元分析 (NMA).
- 使用GRADE框架评估证据确定性;协议注册在PROSPERO.
主要成果:
- 分析了18个出版物,其中有2199名参与者.
- 生油显示了降低术后吐 (POV) 发生率的最高概率 (RR 0.39 [0.16,0.96]).
- 与安慰剂相比,生治疗方案在减少术后恶心 (PON) 方面没有发现统计学上显著的优势;生粉和油的使用和恶心强度减少.
结论:
- 生油在预防手术后吐 (POV) 方面显得优越.
- 生制剂在减少术后恶心 (PON) 方面没有明显的优势.
- 疗效与特定的患者人口统计和手术类型有关.
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