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分子动力学模拟揭示了EF-SAM隐藏的EF手作为可能的关键热传感器,用于通过温度激活STIM1

Andrei Neamtu1, Dragomir N Serban2, Greg J Barritt3

  • 1Department of Physiology, "Grigore T. Popa" University of Medicine and Pharmacy, Iasi, Romania; Center of Advanced Research in Bionanocojugates and Biopolymers, "Petru Poni" Institute of Macromolecular Chemistry Iasi, Iasi, Romania.

The Journal of biological chemistry
|June 28, 2023
PubMed
概括

电流相互作用分子1 (STIM1) 使用其EF-SAM域来感知温度. 隐藏的EF手子域在更高的温度下展开,揭示出一种疏水性残留物,这表明细胞信号传递中存在一种新的温度感应机制.

关键词:
和是最重要的.释放激活通道蛋白1 (Orai1) 释放激活通道蛋白1 (Orai1) 释放激活通道蛋白细胞内膜网膜 (ER) 是一个分子动力学分子动力学流体相互作用分子1 (STIM1)

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