维生素D补充剂和主要心血管事件:D-Health随机对照试验
Bridie Thompson1, Mary Waterhouse1, Dallas R English2
1Population Health Program, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia.
BMJ (Clinical research ed.)
|June 28, 2023
概括
每月补充维生素D可以减少老年人的主要心血管事件. 虽然益处很小,但它建议对维生素D进行进一步的研究.
科学领域:
- 老年学是一门学科.
- 心血管医学 心血管医学
- 营养科学 营养科学
背景情况:
- 心血管疾病仍然是老年人患病和死亡的主要原因.
- 维生素D缺乏症在老年人群中很常见.
- 维生素D补充剂在心血管健康中的作用正在调查中.
研究的目的:
- 确定每月补充维生素D是否会影响60-84岁成年人主要心血管事件的发生率.
- 分析维生素D对特定心血管事件的影响,如心肌梗塞,中风和冠状动脉再血管化.
主要方法:
- 一个随机,双盲,安慰剂对照试验 (D-Health试验) 涉及21,315名参与者.
- 参与者每月接受60,000 IU维生素D3或安慰剂,长达五年.
- 通过行政数据集追踪主要心血管事件,并使用灵活的参数生存模型进行分析.
主要成果:
- 总共有1336个主要心血管事件发生在21,302名参与者中,平均为5年.
- 与安慰剂 (6.6%) 相比,维生素D组的主要心血管事件的发生率略低 (6.0%),危险率为0.91 (95% CI 0.81至1.01).
- 维生素D组中心肌梗塞的发生率明显较低 (HR 0.81,95% CI 0.67~0.98).
结论:
- 对老年人来说,每月补充维生素D可能会适度地减少主要心血管事件.
- 这些发现表明潜在的益处,特别是对于已经服用心血管药物的人来说,需要进一步调查.
- 虽然绝对风险降低很小,但结果鼓励继续研究维生素D在预防心血管疾病中的作用.
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