急性至慢性肝衰竭的临床谱和表现
Andrew R Scheinberg1, Paul Martin1, Kalyan Ram Bhamidimarri1
1Division of Digestive Health and Liver Diseases, University of Miami Miller School of Medicine, Miami, 1120 Northwest 14th Street, Miami, FL 33136, USA.
Clinics in liver disease
|June 28, 2023
概括
急性至慢性肝衰竭 (ACLF) 涉及慢性肝病患者的突然失补偿,导致器官衰竭和更高的死亡率. 这种情况影响到20-40%的住院肝硬化患者,需要特定的诊断标准.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 关键护理医学 关键护理医学
- 内部医学 内部医学
背景情况:
- 急性至慢性肝衰竭 (ACLF) 是慢性肝病的严重并发症.
- 它呈现为与肝外器官功能障碍的突发性去补偿.
- ACLF影响了大量的住院肝硬化患者 (20-40%),增加了死亡风险.
研究的目的:
- 定义和表征急性至慢性肝衰竭 (ACLF).
- 为了突出ACLF在住院肝硬化患者的流行情况.
- 为ACLF引入诊断标准.
主要方法:
- 对ACLF现有文献和诊断标准的审查.
- 对患有慢性肝病和脱补偿的患者群体的分析.
- 专注于北美研究末期肝病研究联盟 (CALD) 的标准.
主要成果:
- 在慢性肝病中,ACLF被定义为具有肝外器官衰竭的急性脱补偿.
- 北美末期肝病研究联盟 (CALD) 的标准包括两个或两个以上器官系统的衰竭.
- 受影响的器官系统包括循环,,神经,凝血病和肺.
结论:
- 急性至慢性肝衰竭 (ACLF) 代表肝病的关键阶段,具有显著的死亡影响.
- 使用已确定的标准进行准确的诊断至关重要,例如北美末期肝病研究联盟 (CALD) 的标准.
- 了解ACLF对于管理晚期慢性肝病患者至关重要.
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