肝移植在急性和慢性肝衰竭中的肝移植
Anand V Kulkarni1, K Rajender Reddy2
1Department of Hepatology, Asian Institute of Gastroenterology, Hyderabad-500032, India.
Clinics in liver disease
|June 28, 2023
概括
急性至慢性肝衰竭 (ACLF) 正在增加,肝移植 (LT) 是最好的希望. 经过LT后的结果取决于ACLF的严重程度,使得时间对患者的生存至关重要.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 移植医学 移植医学
- 临界护理医学 临界护理医学
背景情况:
- 在全球范围内,急性至慢性肝衰竭 (ACLF) 的发生率正在增加.
- ACLF呈现出感染,器官衰竭和高短期死亡率.
- 肝移植 (LT) 是对ACLF最有效的治疗方法.
研究的目的:
- 审查关于急性至慢性肝衰竭 (ACLF) 肝移植 (LT) 的当前文献.
- 评估在ACLF患者中LT的可行性,徒劳性,最佳时间和结果.
- 为管理符合 LT 资格的 ACLF 患者提供洞察力.
主要方法:
- 对ACLF中LT现有研究的系统审查.
- 分析有关患者选择和手术结果的数据.
- 在ACLF中影响移植后生存的因素的评估.
主要成果:
- 对于精选的ACLF患者来说,LT是一种可行的治疗选择,即使有器官衰竭.
- 经过LT的结果受到ACLF的严重程度 (等级) 的显著影响.
- 早期的LT可能会改善严重ACLF患者的生存率.
结论:
- 肝移植是一种可行的,尽管复杂的,急性-慢性肝衰竭的选择.
- 仔细选择患者和考虑ACLF等级对于成功的LT结果至关重要.
- 需要进一步的研究来优化ACLF中LT的时间和管理协议.
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