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在患有扩散型大B细胞淋巴瘤的患者中,无可逆转的内化疗诱导的骨髓病变

Yuri Hirakawa¹, Akihito Kitao¹, Marika Watanabe¹

¹Division of Medical Oncology/Hematology, Department of Medicine, Kobe University Graduate School of Medicine School of Medicine, Japan.

Internal medicine (Tokyo, Japan)

|June 28, 2023

概括

静脉内化学疗法可能会导致罕见但不可逆转的骨髓病在患有血液性恶性瘤的患者. 这一案例凸显了认识到这种神经毒性的重要性,以确保及时的临床意识和管理.

科学领域:

神经学神经学
在瘤学瘤学.
血液学血液学血液学

背景情况:

静脉内化学疗法是中枢神经系统参与血液恶性瘤的标准治疗方法.
神经毒性是一种罕见但严重的潜在副作用.

研究的目的:

报告一例内化疗诱导的骨髓损伤病例.
提高临床医生对这种罕见并发症的认识.

主要方法:

一个74岁的妇女患有扩散性大B细胞淋巴瘤和脊髓损伤的病例报告.
系统化疗和内化疗的使用.
停止使用维生素B12,叶酸和类固醇脉冲的内治疗和支持性护理.

主要成果:

患者在五次静脉内化疗后出现骨髓病变.
尽管接受了支持性治疗,但患者的症状没有改善,这表明潜在的不可逆转性.

结论:

内化疗诱导的骨髓病变是一种罕见但显著的并发症.
早期识别和意识对于在接受血液恶性瘤化疗的患者中管理这种可能不可逆转的疾病至关重要.

关键词:

扩散大的B细胞淋巴瘤.内化学疗法内化学疗法骨髓病变是一种骨髓病变.

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