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Andrew J Kwok¹, Jianning Lu², Junzhe Huang¹

¹Division of Neurology, Department of Medicine and Therapeutics, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong SAR, China; Li Ka Shing Institute of Health Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong SAR, China; Margaret K. L. Cheung Research Centre for Management of Parkinsonism, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong SAR, China; Lau Tat-chuen Research Centre of Brain Degenerative Diseases in Chinese, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong SAR, China; Gerald Choa Neuroscience Institute, The Chinese University of Hong Kong, Hong Kong SAR, China.

Seminars in cell & developmental biology

|June 28, 2023

概括

高分辨率的奥米克揭示了老化和神经退行过程中脑细胞的分子变化. 本综述综合了这些发现,以指导这些疾病的生物标志物发现和治疗开发.

科学领域:

神经科学是一个神经科学.
基因组学就是基因组学.
细胞生物学细胞生物学

背景情况:

衰老和神经退行性疾病涉及脑细胞的复杂变化.
高分辨率的奥米克技术对于理解细胞多样性和功能至关重要.
合成omics数据对于推进神经退行性疾病研究至关重要.

研究的目的:

审查最近在神经血管和质细胞中的omics发现.
专注于功能影响和跨物种差异 (人与老鼠).
要突出与衰老,神经退行,血管缺陷和炎症的联系.

主要方法:

审查单细胞和空间转录基因分析分析的研究.
分子特征和功能影响的分析.
跨物种发现的比较.

主要成果:

正常和老化状态下的状血管细胞的详细分子概况.
确定导致神经退行症的关键分子变化.
对细胞反应的跨物种变异的洞察.

结论:

欧米克斯分析提供了对神经退行性机制的关键见解.
翻译应用包括生物标志物发现和治疗开发.
未来的战略应该利用omics数据进行有针对性的干预.

关键词:

阿尔茨海默氏症是阿尔茨海默氏症的一种疾病.质细胞是质细胞的组成部分.神经退行发生神经退行.神经血管单位神经血管单位俄米克斯 (Omics) 是一个电子游戏.帕金森病是帕金森氏症的一种疾病.单细胞RNA测序的测序方法

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