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强迫症的遗传流行病学:一个系统的审查和元分析
Thiago Blanco-Vieira1, Joaquim Radua2, Lívia Marcelino3
1Child and Adolescent Psychiatry Unit (UPIA), Department of Psychiatry, Federal University of São Paulo (UNIFESP), São Paulo, Brazil. thiagoblanco@escs.edu.br.
Translational psychiatry
|June 28, 2023
概括
强迫症 (OCD) 是一种普遍且高度家族性疾病. 遗传学研究表明,它的遗传性约为50%,受遗传学和环境的影响.
科学领域:
- 精神病学是一个精神病学.
- 遗传学 是一个遗传学.
- 流行病学 流行病学
背景情况:
- 强迫症 (OCD) 的遗传流行病学需要自20年前最后一次重大审查以来的最新知识.
- 最近的研究需要对2001年以后发表的研究进行全面综合.
研究的目的:
- 为强迫症的遗传流行病学提供最新的系统审查和元分析.
- 巩固目前对强迫症家族复发和遗传性的理解.
主要方法:
- 在CENTRAL,MEDLINE,EMBASE,BVS和OpenGrey数据库中进行系统搜索,截至2021年9月30日.
- 纳入标准:经过验证的强迫症诊断,对照组和病例对照,队列或双胞胎研究设计.
- 分析侧重于一级亲属 (FDR) 和双胞胎对相关性.
主要成果:
- 强迫症是一种普遍且高度家族性疾病,特别是在儿童和青少年的亲属中.
- 强迫症的表型遗传率估计约为50%.
- 在单胞胎 (MZ) 与双胞胎 (DZ) 双胞胎中,强迫症症状 (OCS) 的相关性较高,归因于附加遗传或非共享的环境因素.
结论:
- 强迫症显示出显著的家族聚合,强调其遗传基础.
- 遗传概率估计证实了对强迫症有很大的遗传贡献.
- 环境因素,特别是非共享的环境因素,与遗传影响一起也起着至关重要的作用.
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