第三季度皮质类固醇水平升高与后代感染的减少有关
Nicole Prince1, Rachel S Kelly1, Su H Chu1
1Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, 181 Longwood Avenue, Boston, MA, 02115, USA.
Scientific reports
|June 28, 2023
概括
怀孕期间母亲的皮质类固醇水平与后代呼吸道感染的减少有关. 怀孕后期更高的水平与婴儿肺功能更好和感染风险降低相关,这表明潜在的干预措施.
科学领域:
- 围产儿医学 围产儿医学
- 呼吸系统健康 呼吸系统健康
- 内分泌学 在内分泌学.
背景情况:
- 在生命早期重复出现的呼吸道感染会增加慢性疾病的风险.
- 怀孕期间的母亲因素会影响后代对感染的易感性.
- 类固醇在呼吸系统健康和感染易感方面的作用需要描述.
研究的目的:
- 研究怀孕期间母亲的类固醇水平与后代易患呼吸道感染之间的关系.
- 探索母体类固醇与喘和肺功能等相关呼吸系统结果之间的关联.
主要方法:
- 使用了两个产前队列 (VDAART和COPSAC) 与1503个母婴对.
- 通过超高性能液态染色学/质谱学,在三个月的血中测量了16种母亲的雌激素和皮质类固醇代谢物.
- 员工调整了波桑回归模型,以评估与后代呼吸道感染发生率和肺功能之间的关联.
主要成果:
- 在妊娠第三季度,较高的母体血皮质类固醇水平与较低的后代呼吸道感染发病率显著相关 (P < 0.002).
- 第三季度皮质类固醇的增加与后代肺功能指标的改善相关 (P = 0.020-0.036).
- 母亲的雄激素与增加后代感染和较差的肺功能有着不一致的关联.
结论:
- 在怀孕后期增加的母体皮质类固醇水平与减少后代呼吸道感染和增强肺功能有关.
- 这些发现表明孕妇在怀孕晚期补充皮质类固醇作为潜在的干预策略.
- 针对孕产妇的类固醇特征可能会减轻早期呼吸道感染的易感性.
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