怀孕期间母亲的焦虑与成年后代的前额功能连接性较弱有关
Elise Turk1, Marion I van den Heuvel2, Charlotte Sleurs2,3
1Department of Cognitive Neuropsychology, Tilburg University, Warandelaan 2, 5037AB, Tilburg, The Netherlands. e.turk@tilburguniversity.edu.
Brain imaging and behavior
|June 28, 2023
概括
产前暴露于高母性焦虑与成年人脑部连接性较弱有关. 这一发现凸显了母亲心理健康对长期后代福祉和恢复能力的重要性.
科学领域:
- 神经科学是一个神经科学.
- 发展心理学 发展心理学
- 精神病学是一个精神病学.
背景情况:
- 大脑的连接体,每个人的独特,可能是由产前环境塑造的.
- 产前因素可能会影响晚年的人生心理健康和性.
研究的目的:
- 研究产前母亲焦虑对后代大脑功能连接的长期影响.
- 为了确定怀孕期间母亲的焦虑是否与成年后大脑网络的改变有关.
主要方法:
- 在28岁的49名成年人进行前性休息状态功能磁共振成像 (fMRI) 研究.
- 后代分为"高焦虑" (n=13) 和"低到中等焦虑" (n=36) 组,基于孕期 (12-22周) 孕妇焦虑.
- 用于预测功能连接 (ROI-to-ROI和图表指标) 的一般线性模型,以母亲焦虑为预测因素,控制性别,出生体重和产后焦虑.
主要成果:
- 较高的孕产妇焦虑与中部前额叶皮层和左下额叶之间功能连接较弱相关.
- 基于网络的统计数据 (NBS) 证实了这一点,也揭示了左侧前额叶皮层与左体感官运动之间较弱的连接.
- 在与产前暴露于母亲焦虑的成年人中观察到功能连接性减少的一般趋势,尽管全球网络差异并不显著.
结论:
- 产前暴露于高母性焦虑与对后代大脑功能连接的长期负面影响有关,特别是在前额区域.
- 这些发现表明,孕妇在怀孕期间的焦虑可能会在成年后产生持久的影响.
- 建议针对怀孕期间母亲焦虑的普遍初级预防策略,以促进人口层面的心理健康.
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