雷米芬坦尼尔的效果部位度在以埃托米达的麻醉诱导过程中使内内腔输管反应变得麻木:一项剂量确定研究
Zhencong Jiang1,2, Jun Xiao1, Xiaoqing Wang1
1Department of Anesthesiology, Peking University Shenzhen Hospital, Shenzhen, Guangdong province, China.
BMC anesthesiology
|June 28, 2023
概括
这项研究确定了在埃托米达麻醉期间控制输管反应所需的雷米芬坦尼尔效应部位度. 7.731 ng/ml的EC50被发现对50%的患者有效,有助于麻醉实践.
科学领域:
- 麻醉学 麻醉学
- 药理学 药理学是指药理学的学科.
- 临界护理医学 临界护理医学
背景情况:
- 脑内膜输管可以引起显著的血液动力学反应.
- 已知雷米芬坦尼尔可以抑制这些反应.
- 对于化输管反应,需要与埃托米达一起使用的雷米芬坦尼尔的特定度以前是未确定的.
研究的目的:
- 确定Remifentanil的效果部位度,使得50% (EC50) 和95% (EC95) 的患者的气管管道输入反应变得麻木.
- 在etomidate麻醉期间评估这些度.
主要方法:
- 50名美国麻醉学会的身体状况I-II患者接受了目标控制输液 (TCI) 雷米芬坦尼尔,其次是埃托米达和罗库.
- 监测了心血管反应 (MAP,HR) 和镇静/nociception指数 (MGRSSI,MGRNOX).
- 修改后的迪克森上下方法和探头分析被用于计算EC50和EC95.5.
主要成果:
- 确定雷米芬坦尼尔的EC50和EC95分别为7.731 ng/ml和8.701 ng/ml.
- 与负面反应相比,积极的输管反应显示HR,MGRSSI和MGRNOX的显著增加.
- 术后恶心和吐发生在3名患者中,是最常见的不良事件.
结论:
- 效果部位度为7.731 ng/ml的雷米芬坦尼尔有效地抑制了50%的患者在与埃托米达麻醉一起使用时对气管输管进行同情反应.
- 这一发现为优化输管期间麻醉管理提供了有价值的数据.
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