慢性社会失败会改变大脑血管相关细胞基因表达模式,导致血管功能障碍和免疫系统激活
Joshua D Samuels1,2, Madison L Lotstein3, Michael L Lehmann3
1Section on Functional Neuroanatomy, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, 20892, USA. rhk9gh@virginia.edu.
Journal of neuroinflammation
|June 28, 2023
概括
慢性社会压力会损害大脑血管,并改变大脑血管相关细胞 (BVACs). 这项研究引入了一种新方法来分离这些细胞,揭示了精神疾病中神经血管功能障碍的洞察力.
科学领域:
- 神经科学是一个神经科学.
- 血管生物学 血管生物学
- 精神病学是一个精神病学.
背景情况:
- 脑血管完整性对神经健康至关重要,在包括精神疾病在内的各种脑病理中受到干扰.
- 脑血管屏障 (BVACs) 是复杂的细胞结构,但它们在健康和疾病中的作用仍然不明.
- 在老鼠中,慢性社会失败 (CSD) 压力会导致脑血管损伤,包括微型血液,并诱导焦虑和抑郁类行为.
研究的目的:
- 从新鲜的小鼠大脑组织中分离大脑血管相关细胞 (BVACs) 的新技术.
- 鉴定慢性社会失败 (CSD) 后的BVAC群体及其基因表达特征.
- 研究神经血管功能障碍在心理社会压力诱导的大脑病理中的作用.
主要方法:
- 从新鲜的小鼠脑组织中分离与屏障相关的细胞.
- 孤立的BVAC群体的单细胞RNA测序.
- 差异基因表达分析比较CSD压力小鼠与家庭子对照.
主要成果:
- 隔离技术成功丰富了BVAC群体,包括内皮细胞和微质细胞的特定子集.
- 脑血管疾病的压力导致了BVACs中独特的基因表达模式,涉及血管功能障碍,修复和免疫激活的途径.
- 在应对心理社会压力时,观察到BVAC基因表达的显著变化.
结论:
- 已经建立了一种用于从新鲜脑组织中研究BVACs的新方法.
- 心理社会压力导致大脑血管细胞发生显著变化,突出显示神经血管功能障碍.
- 神经血管功能障碍是与心理社会压力相关的大脑病理发展的关键因素.
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