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Pediococcus acidilactici PMC48对高颜色皮肤的临床影响

Hyun-A Park¹, Hoonhee Seo^1,2, Sukyung Kim²

¹Department of Microbiology and Immunology, College of Medicine, Soonchunhyang University, Cheonan, Korea.

Journal of cosmetic dermatology

|June 29, 2023

概括

Pediococcus acidilactici PMC48,是一种益生菌菌株,通过分解黑色素并抑制其合成,有效地减少皮肤色素增多. 这种菌株为皮肤美白和改善皮肤水分提供了安全有效的解决方案.

科学领域:

微生物学微生物学
皮肤病学皮肤病学
化品科学化品科学

背景情况:

超色素是由于过度的黑色素的产生和积累造成的.
目前的黑色素调节技术的有效性和安全性问题有限.

研究的目的:

评估Pediococcus acidilactici PMC48作为皮肤治疗中的益生菌.
评估其在治疗皮肤多颜色的化品和药物应用中的潜力.

主要方法:

一项为期8周的临床试验,涉及22名参与者,他们的皮肤因紫外线辐射而晒黑.
用P. acidilactici PMC48在色的皮肤上.
通过视觉评估,皮肤亮度和黑色素指数测量来评估皮肤美白效应.
使用16S rRNA测序分析皮肤微生物组成.
在体外和体内生物毒性评估.

主要成果:

色皮肤颜色强度 (47.647%) 和黑色素指数 (11.818%) 的显著降低.
增加皮肤亮度 (8.098%) 和改善皮肤水分含量 (20.943%).
增加了11.2%的皮肤微生物群中的Lactobacillaceae,而对其他微生物没有不良影响.
没有观察到体外或体外毒性.

结论:

P. acidilactici PMC48表现出显著的皮肤美白特性.
益生菌菌株有效地分解黑色素,并抑制其合成.
P. acidilactici PMC48是开发用于皮肤疾病的化品和药品的安全和有前途的候选者.

关键词:

这种病原体是Pediococcus acidilactici.在PMC48中使用PMC48 过色素化是一种超色素化.黑色素是什么黑色素是什么微生物组是一个微生物组.

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