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Updated: Jul 25, 2025

An Endothelial Planar Cell Model for Imaging Immunological Synapse Dynamics
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An Endothelial Planar Cell Model for Imaging Immunological Synapse Dynamics

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在pMHC脱离过程中,膜结合的CD4-CD3-TCR复合物的动态仿生模型

Zachary A Rollins1, Roland Faller1, Steven C George2

  • 1Department of Chemical Engineering, University of California, Davis, Davis, California.

Biophysical journal
|June 29, 2023
PubMed
概括

CD4核受体使主要基因相容复合体 (pMHC) 更接近T细胞受体 (TCR),增强T细胞信号传递和稳定性. 这种原子层面的洞察力有助于设计出更好的免疫疗法.

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T Cell Activation and Clonal Selection01:22

T Cell Activation and Clonal Selection

T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...
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