整体合成,结构阐明和扩大生物活性的icosalide A:效果的脂友性和胺替代以胺对其生物活性

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Preparation of Enantiopure Non-Activated Aziridines and Synthesis of Biemamide B, D, and epiallo-Isomuscarine
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Abha Dangi1,2,3, Bharat Pande3,4, Sonia Agrawal2,4

  • 1Central NMR Facility, CSIR-National Chemical Laboratory, Dr Homi Bhabha Road, 411008 Pune, India. m.udayakiran@ncl.res.in.

Organic & biomolecular chemistry
|June 29, 2023
PubMed
概括

实现了第一个icosalide A的全合成,这是一种抗菌性脱类. 这项研究解决了立体化学问题并探索了类似物,揭示了强大的抗菌和抗癌活性,包括对抗Mycobacterium tuberculosis.

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