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在Murrah水牛中检测全基因组拷贝数变异

Harshit Kumar¹, Manjit Panigrahi¹, Maria G Strillacci²

¹Division of Animal Genetics, Indian Veterinary Research Institute, Izatnagar, India.

Animal biotechnology

|June 29, 2023

概括

研究人员在Murrah水牛中确定了副本数变异 (CNV),揭示了改善生产和繁殖特征的遗传标. 这项研究强调了CNVs在水牛遗传改进方面的潜力.

科学领域:

动物遗传学动物遗传学
基因组学就是基因组学.
畜牧科学畜牧科学畜牧科学

背景情况:

穆拉水牛对于乳制品和肉类生产至关重要,以适应性而闻名.
了解像拷贝数变异 (CNVs) 这样的遗传变异对于品种改进至关重要.

研究的目的:

通过使用高密度基因定型来研究Murrah水牛的副本数变异 (CNVs).
为了确定与经济重要特征相关的副本数变异区域 (CNVRs).

主要方法:

使用Axiom®水牛基因型阵列90K.使用296只Murrah水牛的基因型定型.
使用复制号分析模块 (CNAM) 检测和分析CNV.
使用生物信息学工具识别CNVR和基因注释.

主要成果:

在279只水牛中检测到7937个CNV,占基因组的10.33%.
确定了1541个CNVR,其中至少在10只动物中发现了196个.
在CNVR中注释了485个基因,其中40个CNVR中的59个基因与69个特征相关.

结论:

在Murrah水牛品种中发现了显著的CNV和CNVR.
CNVRs携带与生产和繁殖特征相关的基因.
这些发现为标记器辅助选择和基因改进计划提供了潜在的目标.

关键词:

在CNVR中看到的.在CNVs中,可以看到CNVs.在 QTL 时段,你会得到 QTL.河水水牛在河水水牛性格特征性格特征性格特征

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