服用乌尔索多西胆酸并没有降低儿童对SARS-CoV-2感染的易感性
Teng Liu1,2, Jian-She Wang1,2
1The Center for Pediatric Liver Diseases, Children's Hospital of Fudan University, Shanghai, China.
概括
在Omicron激增期间, Ursodeoxycholic acid (UDCA) 并没有降低患有肝病的儿童的SARS-CoV-2感染率. 这项研究发现,在服用UDCA和不服用UDCA的儿童之间,感染易感性没有显著差异.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 传染性疾病 传染性疾病
- 儿科 儿科 儿科
背景情况:
- 之前的研究表明,ursodeoxycholic acid (UDCA) 可能会降低SARS-CoV-2感染风险.
- 最近在中国出现的Omicron变种激增,为研究UDCA在儿科肝病患者的疗效提供了机会.
研究的目的:
- 为了确定UDCA的使用是否降低了患有肝病的儿童对SARS-CoV-2感染的易感性.
- 评估UDCA在高SARS-CoV-2 Omicron变种流通期间对感染率的影响.
主要方法:
- 一份问卷分发给300个家庭的儿童治疗肝病.
- 将服用UDCA的儿童与未服用UDCA的儿童在感染家庭中的SARS-CoV-2感染比例进行比较.
主要成果:
- 在280个有效响应中,226个家庭报告了SARS-CoV-2感染.
- 感染率相似:在接受UDCA的儿童中,感染率为65.1% (n=146),而非UDCA的儿童则为63.8% (n=80).
- 在感染易感性方面没有观察到统计学上显著的差异 (p=0.843).
结论:
- 在患有肝病的儿科患者中,UDCA的使用似乎没有降低对SARS-CoV-2感染的易感性.
- 这些发现不支持UDCA用于预防COVID-19在这个特定的人群中的使用.
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