基拉尔氨基酸修饰的二甲基纳米颗粒具有不同的光动力学活性
Wentao Lei1,2, Qihang Wu1,2, Hui Wen1,2
1State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, Jilin 130022, P. R. China. suntt@ciac.ac.cn.
Journal of materials chemistry. B
|June 29, 2023
概括
研究人员用L-酸 (Asp) 和D-Asp修改了一个分子,以创建纳米粒子. 与D-酸纳米颗粒相比,L-酸纳米颗粒显示出对癌细胞和细菌的光动力疗法疗效优越.
科学领域:
- 生物医学工程 生物医学工程
- 材料科学 材料科学 材料科学
- 光动力学疗法 光动力学疗法
背景情况:
- 氨基酸是基本的生物单位.
- 用氨基酸修改分子可以赋予新的特性.
- 光敏剂对于光动力学疗法 (PDT) 是至关重要的.
研究的目的:
- 为了研究L-酸 (Asp) 和D-Asp修饰对BDP分子的影响.
- 评估修改的BDP纳米粒子 (NP) 的自组装和光动力学治疗疗效.
主要方法:
- 用L-Asp和D-Asp对BDP进行化学修饰.
- 自组装纳米粒子 (NP) 的表征.
- 对抗癌细胞和细菌的光动力疗效的评估.
主要成果:
- 用L-Asp和D-Asp成功修改的BDP产生了BDP-LAsp和BDP-DAsp.
- 由于Asp的水友性,这两种修饰的BDP都自组装成均的纳米粒子.
- 与BDP-DAsp NP相比,BDP-LAsp NP的光动力疗效显著更高.
结论:
- Asp修改为开发光敏剂提供了一个简单的策略.
- Asp的性影响了基于BDP的纳米颗粒的治疗疗效.
- 这种方法有望推动PDT在生物医学应用中的发展.
相关概念视频
Mechanical Protein Functions
Proteins perform many mechanical functions in a cell. These proteins can be classified into two general categories- proteins that generate mechanical forces and proteins that are subjected to mechanical forces. Proteins providing mechanical support to the structure of the cell, such as keratin, are subjected to mechanical force, whereas proteins involved in cell movement and transport of molecules across cell membranes, such as an ion pump, are examples of generating mechanical force.
Studying the Cytoskeleton
The cytoskeletal architecture can be studied using different microscopic and biochemical techniques. Electron microscopy was instrumental in discovering the cytoskeletal architecture around the 1960s, which allowed obtaining structural information at a high-resolution level. However, the sample preparation procedure often limits this ability in biological samples. Several protocols have been developed over the years to optimize sample preparation. In one of the protocols known as rotary...
¹³C NMR: ¹H–¹³C Decoupling
The probability of having two carbon-13 atoms next to each other is negligible because of the low natural abundance of carbon-13. Consequently, peak splitting due to carbon-carbon spin-spin coupling is not observed in spectra. However, protons up to three sigma bonds away split the carbon signal according to the n+1 rule, resulting in complicated spectra.
A broadband decoupling technique is used to simplify these complex, sometimes overlapping, signals. Broadband decoupling relies on a...
A broadband decoupling technique is used to simplify these complex, sometimes overlapping, signals. Broadband decoupling relies on a...
Variables Affecting Phosphorescence and Fluorescence
Fluorescence and phosphorescence are essential phenomena in fields like analytical chemistry, biological imaging, and materials science, where they detect molecular properties and visualize cellular structures. Understanding the variables that influence these luminescent behaviors is crucial for maximizing accuracy and efficiency in their applications. These variables can broadly be grouped into chemical structure, solvent properties, and external conditions, each playing a distinct role in...


