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Updated: Jul 25, 2025

Rapid Generation of Amyloid from Native Proteins In vitro
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Rapid Generation of Amyloid from Native Proteins In vitro

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氨基原性轻链会影响血细胞存活率

Marjorie Pick1, Eyal Lebel2, Sharona Elgavish3

  • 1Department of Hematology, Hadassah Medical Center, Faculty of Medicine, Hebrew University of Jerusalem. marjorie@cc.huji.ac.il.

Haematologica
|June 29, 2023
PubMed
概括

系统性轻链氨基粉症 (AL) 涉及错误折叠的蛋白质. 新的细胞模型揭示AL细胞减少了增殖和增加了压力,解释了它们独特的行为并帮助治疗开发.

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Imaging Amyloid Tissues Stained with Luminescent Conjugated Oligothiophenes by Hyperspectral Confocal Microscopy and Fluorescence Lifetime Imaging

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Use of Two Dimensional Semi-denaturing Detergent Agarose Gel Electrophoresis to Confirm Size Heterogeneity of Amyloid or Amyloid-like Fibers10:10

Use of Two Dimensional Semi-denaturing Detergent Agarose Gel Electrophoresis to Confirm Size Heterogeneity of Amyloid or Amyloid-like Fibers

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相关概念视频

Amyloid Fibrils03:03

Amyloid Fibrils

Amyloid fibrils are aggregates of misfolded proteins.  Under most circumstances, misfolded proteins are either refolded by chaperone proteins or degraded by the proteasome. However, in the case of a mutation or a disease, these proteins can accumulate to form large clusters and often further assemble to form elongated fibers, called fibrils. 
Amyloid deposits were observed as early as 1639 in the liver and the spleen.   In 1854, Rudolph Virchow performed iodine staining,...
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