相关实验视频
Updated: Jul 25, 2025

07:37
An Adoptive Transfer Model of Rheumatoid Arthritis in Mice
Published on: June 6, 2025
217
植物胺通过调节炎症来缓解卡拉基/高诱导的关节炎症状
Bongjun Sur1, Mijin Kim1, Thea Villa1
1Department of Molecular Medicine, School of Medicine, Ewha Womans University, Seoul 07804, Republic of Korea.
Biomolecules & therapeutics
|June 29, 2023
概括
植物胺 (Pcer) 通过减少大鼠模型和突细胞的炎症,显示出显著的抗关节炎作用. 这表明Pcer是Pcer.
科学领域:
- 药理学和毒理学 药理学和毒理学
- 免疫学 免疫学 免疫学
- 生物化学 生物化学
背景情况:
- 植物和酵母中发现的脂质植物胺 (Pcer) 具有已知的神经保护和免疫刺激特性.
- 在关节炎等炎症性疾病中,Pcer的治疗潜力仍然在很大程度上未被探索.
研究的目的:
- 为了研究Phytoceramide (Pcer) 的治疗功效,在一个由卡拉/高 (C/K) 诱导的关节炎的老鼠模型中.
- 评估Pcer对纤维细胞样同胞细胞 (FLS) 中的亲炎性介质的影响.
主要方法:
- 关节炎老鼠在诱导后六天内接受了不同剂量的Pcer (1,10,30毫克/公斤/天) 治疗.
- 关节炎症状通过体重分布比,膝盖厚度,尖叫得分,血清细胞因子水平和组织学分析来评估.
- 干白素 (IL) -1β刺激的FLS患者用Pcer (1-30μM) 治疗,以测量促炎媒介表达.
主要成果:
- 在C/K诱导后的第4至第6天,Pcer治疗显著减少了大鼠的关节炎症状.
- 组织学分析显示,Pcer治疗的老鼠膝关节炎症减少.
- 在IL-1β刺激的FLS中,Pcer有效抑制了促炎媒介体的表达.
结论:
- 植物胺 (Pcer) 在体内老鼠模型和体内突细胞中都表现出显著的抗关节炎作用.
- 由于其抗炎性质,Pcer显示出作为治疗关节炎的治疗剂的潜力.
相关概念视频
Atherosclerosis III: Management
15
Management of atherosclerosis involves an integrated strategy encompassing pharmacological treatment, surgical interventions, lifestyle changes, and nutrition therapy to address the multifactorial nature of the disease.Pharmacological TherapyA cornerstone of atherosclerosis management is the use of pharmacological agents. Statins, such as atorvastatin, are pivotal in inhibiting HMG-CoA reductase, an enzyme that catalyzes an initial step in cholesterol synthesis in the liver. This reduction in...
15
Drugs for Treatment of Crohn's Disease in IBD Using Immunomodulatory Agents
201
Crohn's disease is an inflammatory bowel disorder marked by chronic inflammation of the GI tract. Various treatment strategies for Crohn's disease are employed, such as immunomodulatory agents, glucocorticoids, and biologics or anti-TNF therapy. Azathioprine (Imuran), a commonly used immunomodulatory drug for Crohn's disease, is converted in the body to mercaptopurine, which inhibits purine biosynthesis and cell proliferation. Both are utilized in severe cases of Inflammatory Bowel...
201
T Cell Types and Functions
1.1K
When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
1.1K
Inflammatory Response
2.2K
An inflammatory response is a localized, nonspecific immune reaction that occurs when a tissue is injured. It is characterized by redness, swelling, heat, and pain, which are commonly called the cardinal signs and symptoms of inflammation. Inflammation can sometimes result in a loss of function.
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
2.2K
Drugs for Treatment of Crohn's Disease in IBD Using Glucocorticoids
158
Glucocorticoids, a class of anti-inflammatory drugs, are pivotal in treating moderate to severe Crohn's disease by inducing remission. They exhibit their anti-inflammatory action by inhibiting the production of inflammatory cytokines such as tumor necrosis factor (TNF)-α, interleukin (IL)-1, and chemokines like IL-8. In addition, they reduce the expression of inflammatory cell adhesion molecules and inhibit gene transcription of nitric oxide synthase, phospholipase A2, cyclooxygenase-2...
158
Inflammatory Bowel Disease IV: Pharmacological Management
155
Upon diagnosis, managing Inflammatory Bowel Disease (IBD) involves addressing several crucial aspects. The primary goals include resting the bowel, correcting malnutrition, and providing symptomatic relief. Resting the bowel may consist of medications to reduce inflammation and promote healing. Correcting malnutrition is essential, often requiring dietary adjustments and nutritional supplements. Symptomatic relief aims to ease pain, diarrhea, and other discomforts in IBD.
Pharmacologic...
Pharmacologic...
155

