肠道微生物组和新陈代谢组在移植接受者与正常和适度降低的功能
Yang Lan1, Duo Wang1, Jiayang He1
1Clinical Immunology Translational Medicine Key Laboratory of Sichuan Province and Institute of Organ Transplantation, Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China.
Renal failure
|June 29, 2023
概括
肠道微生物组和代谢物在移植后晚期慢性病 (CKD-T) 的移植接受者 (KTR) 和早期阶段的接受者之间存在差异. 这些变化与功能标志物相关.
科学领域:
- 微生物学 微生物学
- 代谢学 代谢学 代谢学
- 腎臟病學 (nephrology) 是一種醫學專業.
背景情况:
- 移植后慢性病 (CKD-T) 影响移植接受者 (KTRs).
- 肠道微生物组成和代谢物是影响CKD-T的潜在因素.
- 这项研究研究了肠道微生物组与CKD-T中的代谢物之间的相互作用.
研究的目的:
- 用CKD-T. 在KTR中描述肠道微生物组和代谢组.
- 根据CKD-T阶段进展,识别肠道微生物和代谢特征的差异.
- 探索肠道代谢物和功能指标之间的相关性.
主要方法:
- 从KTR收集了100个便样本,按CKD-T阶段分类.
- 在55个样本上进行了Hiseq测序,用于肠道微生物组分析.
- 对100个样本进行了非向的代谢学分析.
主要成果:
- 在CKD G1-2T和CKD G3T组之间观察到肠道微生物群多样性的显著差异.
- 在CKD G3T组中,包括Akkermansia在内的8种细菌种群得到了丰富.
- 参与氨基酸,碳水化合物和纯素代谢的代谢物的差异表达被注意到,N-乙诺尼丁和5-脱氧-5'-(甲基) 腺与功能标志物 (血清肌素,eGFR,cystatin C) 相对应.
结论:
- 肠道微生物组和代谢物概况在CKD-T的进展中表现出独特的特征.
- 不同的肠道微生物和代谢组成与KTRs中CKD-T的不同阶段有关.
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