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电心图年龄与社区环境中的心血管事件之间的关联:弗雷明汉心脏研究
Luisa C C Brant1,2, Antônio H Ribeiro3, Marcelo M Pinto-Filho2
1Faculty of Medicine (L.C.C.B., A.L.P.R.), Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
Circulation. Cardiovascular quality and outcomes
|June 29, 2023
概括
心电图年龄 (心电图年龄) 预测了不良结果. 与时间学年龄相比,较高的心电图年龄表明加快衰老,并且与弗雷明汉心脏研究人口的死亡率和心血管风险增加有关.
科学领域:
- 心脏病学 心脏病学
- 生物标志物 生物标志物
- 人工智能的人工智能
背景情况:
- 深度神经网络从心电图中估计心电图年龄 (ECG-age),预测不良结果.
- 以前的心电图年龄预测仅限于临床环境或短期持续时间.
- 弗雷明汉心脏研究 (FHS) 调查了ECG年龄与社区队列的长期结果的关联.
研究的目的:
- 在FHS中测试ECG年龄与时间年龄的关联.
- 评估心电图年龄,时间年龄差距 (Δage) 和不良心血管结果之间的联系.
- 根据Δage,确定加速或减缓衰老是否预测死亡率和心血管事件.
主要方法:
- 从9887名FHS参与者 (1986-2021) 中使用了ECG.
- 计算的 Δage (时间和心电图年龄之间的差异).
- 采用Cox的比例危险模型来评估与死亡和心血管结果的关联,并对共变量进行调整.
主要成果:
- 电脑心电图年龄与时间年龄有很强的相关性 (r=0.81).
- 每增加10年的Dage都与所有原因的死亡率,心房动,心肌梗塞和心力衰竭的风险更高有关.
- 加快的衰老与增加的死亡率有关;减缓的衰老与减少的死亡率有关.
结论:
- 电脑心电图年龄是FHS中与时间年龄相关的可靠指标.
- 电脑电图年龄和时间年龄之间的差异是死亡率和心血管事件的重要预测指标.
- 电脑心电图-年龄代表了心血管风险评估的可扩展和具有成本效益的生物标志物.
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