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Updated: Jul 25, 2025

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血蛋白质组模式显示了早期同心左心室重塑中的性别差异

Anne-Mar van Ommen1, Ernest Diez Benavente1, N Charlotte Onland-Moret2

  • 1Laboratory of Experimental Cardiology (A.-M.v.O., E.D.B., G.B.V., H.M.d.R.), University Medical Center Utrecht, Utrecht University, the Netherlands.

Circulation. Heart failure
|June 29, 2023
PubMed
概括

集中式重塑 (cRM) 影响大约四分之一的女性和男性,增加了心力衰竭与保存的喷射分数 (HFpEF) 和死亡风险. 炎症通路和IFNA5是女性的关键,这表明了新的治疗点.

关键词:
超声心电图 (Echocardiography) 是一种心声回声仪.心脏衰竭是因为心脏衰竭.干扰子干扰子干扰子预防和控制 预防和控制预后 预后 预后蛋白质组学 蛋白质组学性别特征 性别特征

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Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
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