预测ANCA相关血管炎严重感染的因素
Emine Uslu Yurteri1, Serdar Sezer2, Murat Torgutalp3
1Department of Rheumatology, Ankara University Faculty of Medicine, Ankara, Turkey. drusluemine@gmail.com.
概括
在ANCA相关血管炎 (AAV) 中,严重的感染很常见. 肺干扰,年龄较大和高CRP水平是AAV患者因感染而入院的关键风险因素.
科学领域:
- 类风湿病学 类风湿病学
- 免疫学 免疫学 免疫学
- 传染性疾病 传染性疾病
背景情况:
- 抗中性细胞质抗体 (ANCA) 相关的血管炎 (AAV) 是一种罕见的自身免疫性疾病,其特征是小血管的死性炎症.
- 长期免疫抑制疗法是管理AAV的必要,但它增加了严重感染 (SIs) 的风险.
研究的目的:
- 在被诊断为AAV的患者中,确定需要住院的严重感染的独立风险因素.
主要方法:
- 进行了一项回顾性队列研究.
- 包括84名被诊断患有AAV的患者,并在10年的时间内被安卡拉大学医学院录取.
主要成果:
- 一半的AAV患者 (50%) 经历了需要住院治疗的感染.
- 与感染频率相关的因素包括皮质类固醇剂量,脉类固醇使用,诱导疗法,CRP水平和肺/肺肺参与.
- 严重感染的独立预测因素是肺干扰 (HR=4.95),65岁以上的年龄 (HR=3.37) 和升高的CRP水平 (HR=1.006).
结论:
- 在患有ANCA相关血管炎的患者中,感染更为频繁.
- 肺干扰,晚年和入院时C反应蛋白 (CRP) 水平升高是AAV严重感染的重要独立风险因素.
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