[非细菌病原体在1788名患有社区性肺炎的儿童中的分布]
Shuang Wang1, Xue-Feng Wang, Na Li
1Department of Pediatrics, Affiliated Hospital, Liaoning University of Traditional Chinese Medicine, Shenyang 110032, China.
概括
菌性肺炎 (MP) 和呼吸道同胞病毒 (RSV) 是儿科社区获得性肺炎 (CAP) 的关键病原体. 病原体的分布因儿童的年龄,季节和性别而异.
科学领域:
- 儿童传染病 儿童传染病
- 呼吸系统医学 呼吸系统医学
- 微生物学 微生物学
背景情况:
- 在全球范围内,社区获得性肺炎 (CAP) 是儿童疾病的重要原因.
- 识别致病原体对于有效的治疗和预防策略至关重要.
- 非细菌病原体,包括病毒和非典型细菌,在儿科CAP中发挥着重要作用.
研究的目的:
- 调查儿科CAP中非细菌病原体的分布特征.
- 根据年龄,性别和季节性变化分析病原体的流行率.
- 确定与不同严重程度的肺炎相关的关键病原体.
主要方法:
- 对1788例儿科CAP病例的回顾性分析,这些病例被送往沈阳儿童医院 (2021年12月 - 2022年11月).
- 使用多重RT-PCR和毛细血管电泳检测10种病毒和2种非典型病原体.
- 在血清检测中检测出Chlamydial pneumoniae (Ch) 和Mycoplasma pneumoniae (MP) 抗体.
主要成果:
- 总体病原体阳性率为72.43%,病毒病原体为59.68%,非典型病原体为22.04%.
- 肺炎菌 (MP) 和呼吸道同胞病毒 (RSV) 被确定为最常见的病原体.
- 在不同的季节,年龄组和性别之间观察到病原体分布的显著变化,特定的病原体与严重和叶膜性肺炎有关.
结论:
- MP,RSV,B型流感病毒 (IVB),人体肺转录病毒 (HMPV) 和人体鼻膜病毒 (HRV) 是导致儿童中CAP的主要病原体.
- 病原体患病率表现出与儿科年龄,性别和季节性因素相关的独特模式.
- 了解这些分布特征对于在儿科CAP管理中进行有针对性的干预至关重要.
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