治疗慢性病的药物安全性
1Department of Family Medicine and Community Health, Division of Health System Sciences, UMass Chan Medical School, Worcester, Massachusetts, USA.
Current opinion in nephrology and hypertension
|June 29, 2023
概括
某些药物会使慢性病 (CKD) 恶化并导致损伤. 谨慎的药物选择和剂量调整对于CKD患者至关重要,以避免药物诱导的伤害和损伤.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 药理学 药理学是指药理学的学科.
- 内部医学 内部医学
背景情况:
- 药物诱导的毒性和慢性病 (CKD) 的加速进展是显著的临床问题.
- 识别对CKD患者功能构成风险的药物对于患者安全至关重要.
研究的目的:
- 审查目前关于增加毒性风险的药物的证据.
- 总结关于加速CKD进展的药物的数据.
- 为了突出药物诱导的危害在患有CKD的患者.
主要方法:
- 关于药物对CKD患者影响的最新研究的文献综述.
- 关于毒性和CKD进展的证据分析.
- 在功能障碍的不同阶段对药物安全性概况的评估.
主要成果:
- 双酸盐和催眠药可能会加快CKD的进展;但denosumab不会.
- 诺福维尔二氧化 fumarate (TDF) 携带脏和骨风险,与更安全的TAF和TMF不同.
- 尼马特里尔维尔/里托纳维尔需要适度CKD的剂量调整,不建议在严重CKD; 雷梅西维尔在CKD的安全性正在调查中,而莫尔努皮拉维尔没有剂量调整的需要.
结论:
- 许多药物可以提高急性损伤或CKD进展的风险.
- 谨慎的药物管理,包括剂量优化和选择更安全的替代品,对于减轻慢性病患者的药物诱导伤害至关重要.
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