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合成一种复杂且高效的PCSK9抑制剂

Jeffrey T Kuethe1, Joshua Lee1, David Thaisrivongs1

  • 1Department of Process Research and Development, Merck & Co., Inc., Rahway, New Jersey 07065, United States.

Organic letters
|June 29, 2023
PubMed
概括

一种新的合成方法使得一个强大的proprotein转化酶亚素类/kexin类型9 (PCSK9) 抑制剂能够在克尺度上产生. 这种复杂的分子是使用模块化方法和点击化学组装的,以实现高效的构建.

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