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新型碳纳米酶具有增强的酸酶类催化活性,用于抗微生物应用

Lazzat Nurtay¹, Enrico Benassi², Faisal Nazir³

¹Department of Chemistry, School of Sciences and Humanities, Nazarbayev University, Qabanbay Batyr 53, Nursultan, 010000, Kazakhstan.

|June 29, 2023

概括

硫和联合的碳纳米粒子 (SN-CNPs) 具有强大的酸酶类活性和抗菌性质. 这些来自甜菜粉的新型纳米酶显示出对催化和抗菌应用的前景.

科学领域:

材料科学,纳米技术,生物化学,微生物学

背景情况:

开发具有双重催化和抗微生物功能的新型纳米酶对于先进的应用至关重要.
碳基纳米材料为各种生物医学和工业用途提供可调节的特性.

研究的目的:

从甜菜粉中合成和表征硫和联合的碳纳米粒子 (SN-CNPs).
调查SN-CNPs的酸酶类酶活性和抗菌疗效.
阐明观察到的属性背后的机制.

主要方法:

使用干燥甜菜粉作为碳源的热水合成.
使用传输电子显微镜 (TEM),原子力显微镜 (AFM),里埃变换红外光谱 (FTIR) 和X射线光电子光谱 (XPS) 的表征.
酶活性测定 (迈凯利斯-门动力学) 和对大肠杆菌和乳糖杆菌的抗菌检测.
量子力学计算以模拟与脂的相互作用.

主要成果:

合成的SN-CNPs是圆形纳米颗粒 (直径约50纳米),已证实S和N的兴奋剂.
在Vmax和Km方面,SN-CNPs表现出显著的酸酶类活性,表现优于酸酸酶.
对大肠杆菌 (MIC:63微克/毫升) 和乳糖菌 (MIC:250微克/毫升) 有有效的抗菌活性.
与细菌细胞膜的相互作用和涉及醇组的拟议机制.

结论:

这项研究报告了第一个以碳为基础的纳米粒子,具有强烈的酸酶活性和一种新的模仿酸酶的抗菌机制.
来自生物质的SN-CNPs显示了双重催化和抗菌应用的潜力.
这些发现为开发可持续和有效的纳米酶开辟了道路.

关键词:

基于碳的纳米粒子.酶活性的酶活性.最低抑制度的最小抑制度酸酶和抗微生物特性

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