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性差异和行为关联与典型发展的儿科区域大脑灰质体积和体积

Laura C Rice^1,2, Rebecca N Rochowiak¹, Micah R Plotkin¹

¹Center for Neurodevelopmental and Imaging Research, Kennedy Krieger Institute, 716 N. Broadway, Baltimore, MD, 21205, USA.

Cerebellum (London, England)

|June 29, 2023

概括

一般来说,男性的小脑灰质体积 (GMV) 比女性更大. 性别影响小脑GMV与儿童的运动,认知和情绪功能之间的关系.

科学领域:

神经科学是一个神经科学.
发育神经科学的发展神经科学.
神经成像是一种神经成像.

背景情况:

小脑对运动和高阶功能至关重要,在童年时期显著增长.
关于小脑结构和功能在发育中的儿童之间的性别特异关联的研究有限.

研究的目的:

在典型发育的儿童中,研究小脑灰质体积 (GMV) 区域性性别差异.
检查性行为如何调节小脑GMV与运动,认知和情绪功能之间的关系.

主要方法:

在371名典型发育的儿童 (8-12岁) 中,利用卷积神经网络进行小脑分片.
协调区域GMV使用ComBat来考虑硬件变化.
使用回归分析来评估性别对GMV的影响及其对功能关联的调节.

主要成果:

雄性在几个小脑区域表现出更大的GMV,包括大脑叶I-V,VI,Crus II/VIIb,VIII,X叶和虫区域.
在女性中,较大的运动功能与较少的Vermis VI-VII GMV相关;在男性中,较大的运动/情绪功能与较大的GMV相关.
认知功能与女性左叶VI GMV的增加和男性的减少有关. 内化症状显示,与双边叶片IX GMV的性别特异性相关性.

结论:

研究结果表明,小脑结构及其在童年期间的功能关联中存在性二态模式.
大脑小细胞GMV在男性中较大,其与认知,运动和情绪功能的关系在两性之间存在显著差异.

关键词:

行为协会行为协会大脑小部分的大脑小部分儿科儿科儿科区域灰色物质体积的区域灰色物质体积.性差异性差异性差异性差异性差异性差异性差异性典型的发展典型的发展.

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