一个计算管道,用于对手术后的中枢功能状态的患者特异预测
Hao Liu1, Natalie T Simonian1, Alison M Pouch2
1James T. Willerson Center for Cardiovascular Modeling and Simulation, The Oden Institute for Computational Engineering and Sciences, Department of Biomedical Engineering, The University of Texas at Austin, Austin, TX 78712-1229.
Journal of biomechanical engineering
|June 29, 2023
概括
一个新的计算管道预测了使用手术前成像的关 (MV) 修复结果. 这种方法有助于进行更持久的修复手术规划,并开发出针对患者的MV数字双胞胎.
科学领域:
- 心血管外科心血管外科
- 生物医学工程 生物医学工程
- 计算机建模 计算建模
背景情况:
- 为了弥补 mitra regurgitation (MR) 的 mitra 门 (MV) 修复具有不理想的长期结果.
- 预测修复成功是具有挑战性的,因为不同的MR呈现和修复技术.
研究的目的:
- 开发一种针对患者的计算管道,用于预测维修后的MV功能.
- 量化评估外科手术对MV机械的影响.
主要方法:
- 使用CT和3D回声心脏成像数据创建了MV装置的特定患者的有限元模型.
- 通过模拟手术前关闭和调整小册子/chordae tendineae预训练来校准模型.
- 使用校准模型,模拟小尺寸戒指解环整形 (URA).
主要成果:
- 在三个人体病例中,术后的几何形状在目标距离1mm以内被预测出来.
- 预测的MV传单菌株场与非侵入性估计目标非常相匹配.
- 在复发的病例中,确定了URA后后部叶片结合的增加,这表明了故障机制.
结论:
- 计算管道准确地预测了仅从手术前数据的术后MV修复结果.
- 这种方法支持为持久的MV修复量身定制的手术规划.
- 该管道可以促进对个性化医疗的 mitrale 数码双胞胎的发展.
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