在印度建立一个基于人口的大型前性队列研究的挑战 - - 从LoCARPoN队列研究中得出的教训
Kamal Gulati1, Sada Nand Dwivedi2, Shashi Kant3
1Department of Centralized Core Research Facility, All India Institute of Medical Sciences, New Delhi, India.
The Lancet regional health. Southeast Asia
|June 29, 2023
概括
在印度建立大型人口队伍,比如国家首都地区人口长度认知和衰老研究 (LoCARPoN) 研究,需要精心规划和资源. 主要挑战包括资金和基础设施,强调需要专门支持非西方研究环境.
科学领域:
- 老年学与公共卫生
- 流行病学 流行病学
- 神经科学是一个神经科学.
背景情况:
- 基于人口的前性队列研究对于产生有关健康和衰老的新证据至关重要.
- 在非西方背景下建立这样的研究提出了独特的挑战.
- 国家首都地区人口的长度认知和衰老研究 (LoCARPoN) 是为了解决北印度的这一差距而启动的.
研究的目的:
- 描述LoCARPoN队列的建立,这是印度第一个大规模的,公开资助的关于衰老的研究.
- 调查城市和农村北印度50岁及以上成年人中发生的中风和痴呆症.
- 确定在非西方环境中建立队列的挑战和关键成功因素.
主要方法:
- LoCARPoN队列研究的目标样本大小为15,000名参与者,分布在三个地点,持续了8年 (2014-2022年).
- 该研究重点关注北印度城市和农村地区50岁及以上的成年人.
- 数据收集和基础设施开发面临许多后勤和资源相关的障碍.
主要成果:
- 建立LoCARPoN队伍遇到了重大挑战,包括资金不足,空间不足,招聘人员困难以及缺乏必要的IT和存储基础设施.
- 具体问题包括没有专门的MRI机器,这影响了研究的诊断能力.
- 尽管存在这些障碍,但这项研究为未来该地区老龄化研究提供了基础.
结论:
- 在印度这样的非西方环境中建立大型前性队列研究是可行的,但需要仔细规划和大量资源.
- 关键的成功因素包括足够和持续的资金,训练有素的员工,以及强大的机构和社区支持.
- LoCARPoN的经验为未来在类似环境中的队列发展提供了宝贵的教训,强调了需要强大的基础设施和专门的资金的需要.
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