可能的动物等价的后带状皮层 (区域23) 与多模式皮层和皮层下区域相互连接
Xiao-Jun Xiang1,2, Sheng-Qiang Chen1, Xue-Qin Zhang1
1Department of Psychology, School of Health Management, Guangzhou Medical University, Guangzhou, China.
Frontiers in neuroscience
|June 29, 2023
概括
研究人员确定了灵长类动物后带带皮层 (PCC,A23) 的动物对应物 (A23~). 这一发现使动物模型能够研究大脑电路和阿尔茨海默氏症和精神分裂症等疾病.
科学领域:
- 神经科学是一个神经科学.
- 比较解剖学的比较解剖学
背景情况:
- 后侧环状皮质 (PCC,第23区域) 在人类和灵长类动物的认知过程中至关重要,并与神经疾病有关.
- 在动物中没有定义的PCC,这阻碍了疾病建模和电路研究.
研究的目的:
- 为了识别和描述一个潜在的动物等价的灵长类PCC (A23~).
- 建立用于使用动物模型研究PCC功能和相关病理的基础.
主要方法:
- 使用分子标记物的比较分析.
- 在动物大脑中追踪独特的连接模式.
主要成果:
- 在动物中确定了一个独特的区域 (A23~),显示了与中外 thalamic 核的强烈相互连接.
- 动物A23~与中间脉动,关节和各种皮层区域 (前带膜,后膜,轨道前膜,后膜,视觉和听觉关联皮层) 呈现相互连接.
- A23~ 投射到皮下结构,包括背上条纹体,腹侧生殖细胞核,不确定的区域,前尾细胞核,上角细胞核,周水管灰色和脑干.
结论:
- 已识别的动物A23~与灵长类PCC共享了重要的连接模式,支持其在整合多式传感信息方面的作用.
- 这些发现证实了在未来对PCC结构,功能,病理学和神经调节的研究中使用动物的有效性,从而促进了我们对认知和疾病的理解.
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