感染高病毒性Mycobacterium结核病引发紧急骨髓形成,但没有训练的免疫力
Ana Raquel Maceiras1,2, Diogo Silvério1,3, Rute Gonçalves1,3
1Instituto de Investigação e Inovação em Saúde (i3S), Universidade do Porto, Porto, Portugal.
Frontiers in immunology
|June 29, 2023
概括
在小鼠中的结核病感染刺激了紧急骨髓形成,增加了骨髓中的髓状细胞的产生. 然而,这种反应并没有诱导训练免疫力,并且部分独立于IFNγ,突出了菌株特异性宿主免疫反应.
科学领域:
- 免疫学 免疫学 免疫学
- 血液形成 血液形成 血液形成
- 传染性疾病 传染性疾病
背景情况:
- 感染引发紧急骨髓形成,增强骨髓状细胞的产生和潜在的训练免疫力.
- 结核病 (TB) 感染涉及骨髓 (BM),但与M.结核病H37Rv.观察到有限的紧急骨髓形成和训练免疫力.
- 了解宿主对不同Mycobacterium结核病菌株的反应至关重要.
研究的目的:
- 在感染高病毒性M.结核病菌株 (HN878) 期间调查骨髓中的紧急骨髓形成和训练免疫力.
- 为了确定是否紧急骨髓形成与结核病期间在骨髓中训练有素的免疫结合在一起.
- 评估IFNγ在M.结核病引起的紧急骨髓形成中的作用.
主要方法:
- 在C57BL/6小鼠中,有高剂量的M.结核病HN878.8.的气溶感染.
- 对骨髓变化的监测,包括原生细胞群 (LSK,GMP) 和成熟的髓状细胞.
- 对训练有素免疫标记物的单细胞/巨细胞的分析和IFNγ缺乏小鼠的紧急骨髓形成的评估.
主要成果:
- 结核病HN878感染增加了骨髓中的LSK和GMP种群.
- 在血液和肺部观察到单细胞和中性粒细胞的增加,这表明髓质输出增加.
- 来自受感染小鼠的单细胞/巨细胞没有表现出训练有素的免疫力,这表明解.
- 紧急骨髓形成发生独立于IFNγ.
结论:
- 超病毒性M. tuberculosis HN878诱导骨髓中的紧急骨髓形成,但不会赋予训练免疫力.
- 在M.结核病感染期间,紧急骨髓形成和训练有素的免疫是分离的.
- 宿主对M.结核病的反应受到病原体菌株的影响,并且可以独立于IFNγ.
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