相关实验视频

Updated: Jul 25, 2025

Protective Efficacy and Pulmonary Immune Response Following Subcutaneous and Intranasal BCG Administration in Mice

Protective Efficacy and Pulmonary Immune Response Following Subcutaneous and Intranasal BCG Administration in Mice

Published on: September 19, 2016

关于BCG疫苗接种政策,自然增强和儿科大脑和中枢神经系统瘤发病率

Samer Singh¹, Amita Diwakar², Rakesh K Singh³

¹Centre of Experimental Medicine & Surgery, Institute of Medical Sciences, Banaras Hindu University, Varanasi, India.

Frontiers in immunology

|June 29, 2023

概括

巴西尔·卡尔梅特-盖林 (BCG) 疫苗接种和自然的Mycobacterium再暴露可能显著降低儿童早期大脑和中枢神经系统瘤的发生率. 这表明免疫训练可能是预防儿童癌症的保护因素.

科学领域:

免疫学免疫学免疫学
儿科瘤学儿科瘤学
疫苗学疫苗学疫苗学

背景情况:

众所周知,Bacille Calmette-Guérin (BCG) 疫苗可以诱导"训练免疫力",增强对各种病原体的免疫反应.
全球BCG疫苗接种政策发生了变化,发达国家的授权减少,其他地方的新生儿单剂量减少.
已经观察到早期儿童大脑和中枢神经系统 (BCNS) 瘤的同时增加,促使对免疫因素的调查.

研究的目的:

调查BCG疫苗接种政策与儿科BCNS瘤发病率之间的潜在关联.
探索"训练免疫力"和自然菌根菌暴露的作用,作为预防儿童BCNS癌症的保护变量.
综合现有证据,并强调需要进一步研究癌症预防的免疫调节.

主要方法:

在BCG疫苗接种政策不同的国家对BCNS癌症发病率的比较分析.
在幼儿中BCG接种状态,自然Mycobacterium再暴露的可能性和BCNS癌症率之间的统计相关性.
对影响儿科癌症发展的免疫学因素的现有文献进行审查和综合.

主要成果:

与非BCG国家相比,新生儿BCG疫苗接种的国家在0-4岁儿童中BCNS瘤的发病率明显较低 (P<0.0001).
更高的可能性是自然的Mycobacterium spp. 再暴露与BCNS癌症发生率有负相关性 (r=-0.6085,P<0.0001).
新生儿BCG疫苗接种和自然增强似乎与BCNS癌症发病率减少15-20倍有关.

结论:

新生儿BCG疫苗接种和自然暴露于Mycobacterium可能会对儿童早期的BCNS癌症提供显著的保护.
由BCG或自然感染诱导的免疫训练是对儿科BCNS瘤的一种合理的保护机制.
进一步的受控临床试验和基于注册表的研究是有必要的,以评估免疫训练作为减少儿童BCNS癌症发病率的战略.

关键词:

这是BCG疫苗.这种细菌是Mycobacterium spp.大脑和中枢神经系统癌症癌症的发现发现.预防癌症预防癌症儿童疫苗接种儿童疫苗接种儿科癌症儿科癌症训练有素的免疫力

更多相关视频

Stereotactic Adoptive Transfer of Cytotoxic Immune Cells in Murine Models of Orthotopic Human Glioblastoma Multiforme Xenografts

Stereotactic Adoptive Transfer of Cytotoxic Immune Cells in Murine Models of Orthotopic Human Glioblastoma Multiforme Xenografts

Published on: September 1, 2018

Isolation and Flow Cytometric Analysis of Glioma-infiltrating Peripheral Blood Mononuclear Cells

Isolation and Flow Cytometric Analysis of Glioma-infiltrating Peripheral Blood Mononuclear Cells

Published on: November 28, 2015

相关概念视频

Cancer Vaccines

Cancer Vaccines

Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...

Vaccinations

Vaccinations

Tumor Immunotherapy

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.

Microorganisms in Medicine and Therapeutics

Microorganisms in Medicine and Therapeutics

Microorganisms play a fundamental role in vaccine development, gene therapy, and therapeutic production. Their biological properties are harnessed to advance medicine and public health. Beyond immunization, microorganisms contribute to gut health, antibiotic synthesis, and genetic disease treatment.Live Attenuated and Inactivated VaccinesLive attenuated vaccines, such as the measles, mumps, and rubella (MMR) vaccine, utilize weakened forms of pathogens to closely resemble natural infections.