肠道微生物群的改变与糖尿病视网膜病变及其严重程度有关:从中国东南海岸采集的样本
Xue-Mei Gu1,2, Chao-Yin Lu3, Jian Pan4
1Department of Endocrinology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, Zhejiang Province, China.
World journal of diabetes
|June 29, 2023
概括
肠道微生物群的变化与糖尿病视网膜病变 (DR) 和其严重程度有关. 调节肠道微生物群组成可能为预防DR提供一个新的策略,特别是增殖性糖尿病视网膜病变 (PDR).
科学领域:
- 微生物组研究的研究.
- 眼科医生 眼科 眼科
- 内分泌学 在内分泌学.
背景情况:
- 糖尿病视网膜病变 (DR) 是导致视力障碍的主要原因,目前的治疗方法有局限性.
- 动物研究表明,修改肠道微生物群可以预防视网膜病变.
- 了解肠道微生物群在DR中的作用对于开发新型治疗策略至关重要.
研究的目的:
- 研究来自中国东南海岸的患者的肠道微生物群和糖尿病视网膜病变 (DR) 之间的联系.
- 根据肠道微生物群的改变,确定潜在的DR新型预防和治疗方法.
- 探索DR患者的特定肠道细菌和临床指标之间的相关性.
主要方法:
- 从非糖尿病对照组 (n=15) 和糖尿病患者 (n=30) 收集了便样本,包括DR患者 (n=15) 和没有DR患者 (n=15).
- 使用16S rRNA测序来分析肠道微生物群的组成.
- 组间进行了比较,包括患有增殖性糖尿病视网膜病变 (PDR) 和没有PDR (NPDR) 的患者,并对临床指标进行了相关性分析.
主要成果:
- 在DR和非DR组之间,或PDR和NPDR组之间,没有观察到α和β多样性的显著差异.
- 在DR患者中,特定的细菌家族 (Fusobacteriaceae,Desulfovibrionaceae,Pseudomonadaceae) 和属 (Fusobacterium,Pseudomonas,Adlercreutzia) 的增加.
- 几种属与临床标记物有显著的相关性,包括 Pseudomonas 具有 NK 细胞数量,以及 Acetanaerobacterium 和 Desulfovibrio 具有禁食胰岛素.
结论:
- 肠道微生物群的变化与研究人口中糖尿病视网膜病变 (DR) 的存在和严重程度有关.
- 机制可能涉及短链脂肪酸生产,血管透性和炎症/代谢标志物.
- 调节肠道微生物群代表了DR预防的有希望的新战略,特别是对于PDR.
相关概念视频
Development of Human Microbiota
The human microbiota begins developing at birth and undergoes continual change as we age. Infancy marks a critical period of microbial sensitivity, offering a “window of opportunity” during which beneficial microbes help mature the immune system. By age three, children typically develop a more stable and diverse microbial community. Newborns acquire microbes from their immediate environment; vaginal delivery favors maternal vaginal microbes, while cesarean births favor microbes from the skin...
Microbiome of the Eye
The human eye has a specialized microbiota that reflects its unique anatomical and immunological environment. This low-biomass microbial community predominantly colonizes the conjunctiva and eyelid margins, playing a vital role in ocular surface homeostasis and defense. Despite its proximity to the richly colonized facial skin, the ocular surface maintains a distinct microbial profile due to continuous mechanical and biochemical defense mechanisms.The conjunctival surface hosts fewer microbial...
Dysbiosis of the Gut Microbiota
The human gut microbiome includes a diverse array of microbial species, including beneficial commensals and opportunistic pathogens, which interact to support host health. These microbes contribute to essential functions such as nutrient metabolism, immune system modulation, and maintenance of intestinal barrier integrity. However, disruptions to this equilibrium—referred to as dysbiosis—can have widespread physiological consequences.Dysbiosis is often characterized by reduced microbial...
Diabetic Retinopathy
DefinitionDiabetic retinopathy is a microvascular complication of diabetes affecting the retinal blood vessels.Risk FactorsDiabetic retinopathy is present in almost all individuals with type 1 diabetes and more than 60% of those with type 2 diabetes after two decades of disease.The risk increases with poor glycemic control, hypertension, dyslipidemia, smoking, pregnancy, and puberty.Although cataracts and glaucoma are also more frequent in people with diabetes, retinopathy remains the leading...


