评估黑素对精神分裂患者积极和消极症状的影响:一个随机的安慰剂受控研究
Forouzan Behrouzian1, Leila Abdi1, Masoumeh Nazarinasab1
1Department of Psychiatry, School of Medicine, Golestan Hospital, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
Iranian journal of psychiatry
|June 29, 2023
概括
在精神分裂症患者中,六周的黑补充剂显著降低了负面症状. 这一发现表明,黑激素可能是治疗精神分裂症的有益辅助疗法.
科学领域:
- 精神病学是一种精神病学.
- 神经科学是一个神经科学.
- 药理学 药理学是指药理学的学科.
背景情况:
- 精神分裂症是一种严重的精神疾病,具有积极和消极症状.
- 目前的治疗主要针对积极的症状,使得消极的症状往往无法得到充分的解决.
研究的目的:
- 调查黑激素在缓解精神分裂症在住院患者的积极和消极症状方面的疗效.
- 为了评估六周的黑激素干预对症状严重性的影响.
主要方法:
- 一项随机,双盲,安慰剂对照试验与46名精神分裂症住院患者进行.
- 参与者每天接受6毫克黑激素或安慰剂六周.
- 在基线,三周和六周使用阳性和阴性症状量表 (PANSS) 评估症状严重程度.
主要成果:
- 在基线或三周后的组之间没有观察到PANSS得分的显著差异.
- 六周后,与安慰剂组相比,黑激素组的负面症状显著减少 (P = 0.036).
- 这两组在第六周内在所有PANSS分数中都表现出显著的群体内改善.
结论:
- 长期使用黑激素 (至少六周) 可以改善精神分裂症的负面症状.
- 黑色素可以作为抗精神病药物的有效辅助治疗,可能提高整体症状管理.
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