了解托奎特诺病毒 (TTV) 是一种免疫标记物
Edmund J Gore1, Lilli Gard1, Hubert G M Niesters1
1Department of Medical Microbiology, University Medical Center Groningen, University of Groningen, Groningen, Netherlands.
Frontiers in medicine
|June 29, 2023
概括
血中的托尔奎特诺病毒 (TTV) 病毒载量可能表明免疫状况,特别是在器官移植患者中. 然而,解释TTV水平需要考虑病毒因素,而不仅仅是免疫抑制.
科学领域:
- 病毒学 病毒学
- 免疫学 免疫学 免疫学
- 移植医学 移植医学
背景情况:
- 托奎特诺病毒 (TTV) 是一种普遍存在的anellovirus,是人类病毒组的一部分,其复制受免疫系统功能的影响.
- 假设TTV血病毒载量与免疫抑制程度相关.
- 目前正在研究TTV作为各种免疫相关疾病中免疫能力的潜在标志物.
研究的目的:
- 审查TTV病毒载荷作为免疫能力标记物的潜力.
- 在实体器官移植接受者中探索TTV量化的实用性.
- 确定临床实践中关于TTV测量的挑战和未回答的问题.
主要方法:
- 这篇叙事综述综合了有关Torquetenovirus (TTV) 的现有文献.
- 它检查了与移植患者感染和排斥风险相关的TTV病毒载量的研究.
- 它讨论了影响TTV负载解释的因素,如传播,热带,基因型和突变.
主要成果:
- 在器官移植受体中,高TTV负载与感染风险增加有关.
- 器官移植受体的低TTV负载与排斥风险增加有关.
- 测量TTV病毒载量正在与药物水平进行比较,以监测抗拒疗法.
结论:
- TTV病毒载量显示出作为免疫功能低下个体,特别是移植受体免疫状况指标的前景.
- 解释TTV负载需要考虑病毒特征,而不仅仅是免疫状态.
- 需要进一步的研究来解决复杂性,并确定TTV测量的临床实用性.
相关概念视频
Immune Response Against Viral Pathogens
830
The immune system's response to viral infections is a complex and coordinated process involving natural killer (NK) cells, T cell-mediated responses, and antibody-mediated responses.
NK Cells
NK cells are a crucial part of our innate immune system, acting as the first line of defense against viral infections. These cells can recognize and kill infected cells without prior exposure to the virus, effectively slowing down the spread of infection. Additionally, NK cells produce proinflammatory...
NK Cells
NK cells are a crucial part of our innate immune system, acting as the first line of defense against viral infections. These cells can recognize and kill infected cells without prior exposure to the virus, effectively slowing down the spread of infection. Additionally, NK cells produce proinflammatory...
830
Antigens Involved in Adaptive Immunity
563
An antigen is any substance the immune system identifies as foreign and potentially harmful to the body, prompting an immune response. Antigens have two functional properties: immunogenicity and reactivity. Immunogenicity is the ability of an antigen to stimulate a specific immune response. At the same time, reactivity describes the antigen's ability to react with the cells and antibodies produced in response to it.
Complete Antigens
Complete antigens possess both immunogenicity and...
Complete Antigens
Complete antigens possess both immunogenicity and...
563
Immunological Memory
694
Immunological memory, a pivotal pillar of the adaptive immune system, is responsible for the body's ability to remember and respond more swiftly and effectively to previously encountered pathogens. This remarkable feature is what makes vaccines so effective in preventing diseases.
What is Immunological Memory?
Immunological memory is an integral function of the immune system that allows it to recognize and react more rapidly and effectively to pathogens previously encountered. This feature...
What is Immunological Memory?
Immunological memory is an integral function of the immune system that allows it to recognize and react more rapidly and effectively to pathogens previously encountered. This feature...
694
Humoral Immune Responses
73.2K
Overview
73.2K
Enzyme-Linked Immunosorbent Assay
13.8K
In 1971, Peter Perlman and Eva Engvall developed an Enzyme-linked immunosorbent assay (ELISA or EIA). ELISA differs from western blot in that the assays are conducted in microtiter plates or in vivo rather than on an absorbent membrane.
There are many different types of ELISAs, but they all involve an antibody molecule whose constant region binds an enzyme, leaving the variable region free to bind its specific antigen. Enzyme-substrate reaction allows the antigen to be visualized or...
There are many different types of ELISAs, but they all involve an antibody molecule whose constant region binds an enzyme, leaving the variable region free to bind its specific antigen. Enzyme-substrate reaction allows the antigen to be visualized or...
13.8K
Immunoprecipitation
5.6K
Immunoprecipitation, or IP, is a widely used technique that employs protein-antibody interactions to isolate proteins or protein complexes in their native state for studying protein-protein interactions, quaternary structures, or supramolecular complexes. Various modifications of the technique, including chromatin IP, cross-linking IP, and fluorescence IP, are commonly used.
Chromatin Immunoprecipitation
Chromatin immunoprecipitation, also known as ChIP, is used to study protein-DNA or...
Chromatin Immunoprecipitation
Chromatin immunoprecipitation, also known as ChIP, is used to study protein-DNA or...
5.6K


