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一种益生菌和草药补充剂用于肺部健康的临床试验
Nancy M Wenger1, Luhua Qiao1, Teodora Nicola1
1Division of Neonatology, Department of Pediatrics, University of Alabama at Birmingham, Birmingham, AL, United States.
Frontiers in nutrition
|June 29, 2023
概括
这项研究发现Lactobacillus益生菌和草药混合物对健康和喘患者都是安全的. 喘患者的参与者表现出改善的肺功能和肠道微生物群健康状况,这表明肠肺轴有潜在的益处.
科学领域:
- 微生物组研究的研究.
- 免疫学 免疫学 免疫学
- 肺部病理学 肺部病理学
背景情况:
- 肠道微生物组失调与通过肠肺轴的肺部疾病有关.
- 蛋白质细菌可能会加剧肺炎和损伤.
- 研究益生菌对肠肺轴调节的作用至关重要.
研究的目的:
- 评估 Lactobacillus 益生菌和草药混合物的安全性和耐受性.
- 探索混合物对健康和喘患者肠肺轴的影响.
- 评估对肺功能,生活质量和微生物群生态的影响.
主要方法:
- 一个为期1个月的开放标签随机临床试验,涉及健康和喘患者.
- 参与者每天两次食用益生菌和草药混合物.
- 主要终点:安全;次要终点:肺功能,微生物组分析,炎症生物标志物.
主要成果:
- 混合物耐受性良好,没有报告任何不良事件.
- 喘患者的肺功能 (FEV) 和血清短链脂肪酸显著改善.
- 肠道微生物组分析显示了喘患者的明显差异,特别是大肠杆菌的丰富性,益生菌维持了整体微生物结构.
结论:
- 通过肠肺轴,Lactobacillus益生菌和草药混合物显示出安全性和有效性的承诺.
- 需要进一步的盲目,安慰剂对照试验来证实这些初步发现.
- 这种干预措施需要进一步调查,以管理与肠道失调相关的肺部疾病.
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