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相关概念视频

What is Gene Expression?01:42

What is Gene Expression?

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Overview
Gene expression is the process in which DNA directs the synthesis of functional products, that is, proteins. Cells can regulate gene expression at various stages. It allows organisms to generate different cell types and enables cells to adapt to internal and external factors.
Genetic Information Flows from DNA to RNA to Protein
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Recombinant DNA technology called transgenesis is often used to add a foreign gene or remove a detrimental gene from an organism. Such genetically modified organisms are called transgenic organisms.
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Reporter genes are a type of protein-coding gene that are often tagged to a gene of interest. Once inside a target cell, reporter genes usually produce visually identifiable characteristics like fluorescence and luminescence when expressed along with the gene of interest. Thus, reporter genes “report” the presence or absence of genes of interest in an organism, determine the gene expression pattern, or track the physical location of a DNA segment or protein in the cell.
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In order to produce glucose, plants need to capture sufficient light energy. Many modern plants have evolved leaves specialized for light acquisition. Leaves can be only millimeters in width or tens of meters wide, depending on the environment. Due to competition for sunlight, evolution has driven the evolution of increasingly larger leaves and taller plants, to avoid shading by their neighbors with contaminant elaboration of root architecture and mechanisms to transport water and nutrients.
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Plant cells communicate to coordinate their cycle of growth, flowering and fruiting, and activities in roots, shoots, and leaves in response to the changing environmental conditions. Plant signaling is distinct from animal signaling. Plants primarily utilize enzyme-linked receptors, whereas the largest class of cell-surface receptors in animals are G-protein coupled receptors (GPCRs). Unlike animals, receptor tyrosine kinases are rare in plants. Instead, plants have a diverse class of...
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相关实验视频

Updated: Jul 25, 2025

Annotation of Plant Gene Function via Combined Genomics, Metabolomics and Informatics
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使用知识图来推断植物中的基因表达.

Anne E Thessen1, Laurel Cooper2, Tyson L Swetnam3

  • 1Department of Biomedical Informatics, University of Colorado Anschutz Medical Campus, Aurora, CO, United States.

Frontiers in artificial intelligence
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概括
此摘要是机器生成的。

了解物种间的基因表达是适应气候变化的关键. 这项研究表明,虽然同源基因具有共同的祖先,但预测表型需要在知识图中整合cis和跨调节元素.

关键词:
基因表达的基因表达方式知识图 (KG) 是一个知识图.在本体论上,本体论是存在的.现象型 现象型 是一种现象型.植物基因组 植物基因组

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科学领域:

  • 植物生物学 植物生物学
  • 生物信息学是一种生物信息学.
  • 基因组学就是基因组学.

背景情况:

  • 气候变化影响生态系统和农业,需要适应战略.
  • 了解跨物种的基因型-环境-表型 (G×E×P) 动态对于弹性至关重要.
  • 基因调节网络对于预测表型至关重要,物种之间的知识转移可以加速这种理解.

研究的目的:

  • 开发一个知识图 (KG),整合基因表达,分子相互作用和功能.
  • 通过同类推断来研究基因型-环境-表型动态,用于跨物种知识应用.
  • 评估cis和跨调节元素在干旱压力下预测同源基因表达模式中的作用.

主要方法:

  • 使用Planteome和EMBL-EBI表达式图谱的数据构建了一个KG.
  • 在干旱条件下分析了Arabidopsis thaliana*和Populus trichocarpa*的基因表达数据.
  • 利用图表查询来识别同源基因,并分析它们的cis-regulatory区域.

主要成果:

  • 确定了16个同类基因对,分别是*A. thaliana*和*P. trichocarpa*,在干旱期间表达模式不同.
  • 具有类似表达干旱反应的同类基因表现出保存的cis调节区域和跨元素相互作用.
  • 具有相反表达模式的同源基因在调节元素中显示出分歧.

结论:

  • 预测基因表达和表型的同质推断需要仔细整合cis和跨调节信息.
  • 知识图可以促进基因调节网络的跨物种比较.
  • 这种方法有助于理解和预测植物对干旱等环境变化的反应.