在服用阿特佐利祖马布时出现暂时严重的中性:一篇新的病例报告
Ryota Kanno1, Yoshitaka Saito1, Yoh Takekuma1
1Department of Pharmacy, Hokkaido University Hospital, Sapporo, Japan.
Case reports in oncology
|June 29, 2023
概括
严重的中性质衰竭 (中性粒细胞数量低) 可能在肺癌的阿特佐利祖马布免疫疗法中暂时发生. 及时治疗和监测允许继续治疗和长期疗效.
科学领域:
- 在瘤学瘤学.
- 免疫治疗是一种免疫疗法.
- 血液学 血液学 血液学
背景情况:
- 阿特佐利祖马布是一种免疫检查点抑制剂,用于癌症治疗.
- 严重的中性质减退是一种潜在的,虽然不常见的,与免疫疗法相关的不良事件.
研究的目的:
- 在治疗晚期肺腺癌的阿特佐利祖马布单一治疗期间报告暂时严重的中性质减退病例.
- 描述这种不良事件的管理和结果.
主要方法:
- 一名患有第四阶段肺腺癌的患者接受了阿特佐利祖马布作为第六线治疗.
- 患者患有4级中性质衰竭和3级白血病.
- 治疗包括花细胞殖民地刺激因子 (列诺格拉斯蒂姆) 和抗生素,然后重新开始服用阿特佐利祖马布.
主要成果:
- 患者在阿特佐利祖马布治疗的第三个周期中经历了暂时严重的中性质衰竭和白血病衰竭.
- 在停止阿特佐利祖马布治疗并开始服用列诺格拉斯蒂姆后恢复的中性粒细胞和白细胞数量.
- 阿特佐利祖马布成功恢复,在2年内没有进一步的血液毒性.
结论:
- 暂时严重的中性质是阿特佐利祖马布单独治疗可能发生的免疫相关不良事件.
- 谨慎的监测和支持性护理,包括颗粒细胞殖民地刺激因子,可以使免疫治疗的继续.
- 血液学不良事件的识别和管理对于持续的癌症治疗疗效至关重要.
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