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Updated: Jul 25, 2025

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在PTEN突变皮质器官中细胞类型特异性缺陷汇聚在异常电路活动上

Martina Pigoni1,2, Ana Uzquiano1,2, Bruna Paulsen1,2

  • 1Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA.

Human molecular genetics
|June 29, 2023
PubMed
概括

酸酶和张素同类素 (PTEN) 的突变扰乱了人类大脑的发育. 这些PTEN基因突变导致细胞类型特定的时间异常,导致自闭症谱系障碍中神经元电路活性发生变化.

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