饮食限制减轻了与年龄相关的小鼠B细胞受体谱系多样性下降
Carolina Monzó1, Lisonia Gkioni2, Andreas Beyer3
1Department Biological Mechanisms of Ageing, Max Planck Institute for Biology of Ageing, 50931 Cologne, North Rhine Westphalia, Germany; Cologne Excellence Cluster on Cellular Stress Responses in Age-Associated Diseases (CECAD), Faculty of Medicine and Faculty of Mathematics and Natural Sciences, University of Cologne, 50931 Cologne, Germany.
Cell reports
|June 29, 2023
概括
饮食限制 (DR) 在老化过程中保持免疫B细胞受体多样性. 这种干预保护了免疫功能和健康,即使是在晚年开始的.
科学领域:
- 免疫学 免疫学 免疫学
- 衰老研究研究 衰老研究
- 营养科学 营养科学
背景情况:
- 老龄化导致对新威胁的免疫反应减弱,影响病原体防御和疫苗的有效性.
- 已知饮食限制可以延长寿命和健康,但其对免疫衰老的影响尚不清楚.
- B细胞受体 (BCR) 的多样性对适应性免疫非常重要.
研究的目的:
- 为了研究饮食限制 (DR) 在衰老过程中如何影响B细胞受体 (BCR) 谱.
- 为了确定DR是否可以减轻与年龄相关的免疫功能下降.
- 探索BCR曲目动态与衰老中的健康之间的关系.
主要方法:
- 从老年小鼠的脏样本中测序B细胞受体 (BCR) 重链的可变区域.
- 在DR和对照组之间比较BCR曲目多样性和克隆扩张率.
- 分析脏和肠道组织中与年龄和DR相关的变化.
主要成果:
- 在整个衰老过程中,DR保留了BCR谱的多样性,并减少了中的克隆扩张.
- 在中年开始DR产生了与慢性DR相似的好处,保留了脏免疫指标.
- 肠道BCR曲目特征不受年龄或DR的影响.
结论:
- 饮食限制 (DR) 是一种强有力的干预措施,可以在衰老期间维持脏中免疫B细胞受体谱的多样性和功能.
- 抗逆转录的开始时间 (早期与中年) 并没有显著改变它对脏免疫指标的有益影响.
- 与B细胞谱系多样性的年龄相关的变化与患病率有关,这突显了它对健康的重要性.
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