在喷气式飞机飞行员的基因型,高G耐受性和身体组成的关联
1Department of Aero Fitness, Republic of Korea Air Force Academy, Cheongju, Chungbuk 28187, Republic of Korea.
Military medicine
|June 29, 2023
概括
α-actinin3 (ACTN3) RR基因型和血管激素转化酶 (ACE) DI基因型与战斗机飞行员更好的高g耐受性有关. 这表明在高强度运动期间对生理应激反应的综合遗传影响.
科学领域:
- 体育科学 运动科学 运动科学
- 人体生理学 人体生理学
- 遗传学 是一个遗传学.
背景情况:
- 高性能喷气式飞行员需要+8.5Gz的容忍度,通过离心机评估,模拟高强度的运动.
- 阿尔法-actinin3 (ACTN3) 和血管激素转化酶 (ACE) 基因被公认为可能影响运动表现的"体育基因".
研究的目的:
- 调查ACTN3和ACE基因型与韩国F15和F16飞行员的+8.5Gz耐受性之间的相关性.
- 探索这些遗传变异与飞行员身体组成之间的关系.
主要方法:
- 81名韩国F15/F16飞行员进行了+8.5Gz的离心机测试.
- 运动耐受性被测量为高g暴露期间的平均呼吸间隔.
- 鉴定了ACTN3和ACE基因型,以及身体组成分析.
主要成果:
- 在ACTN3基因型中:RR (28.4%),RX (50.6%),XX (21.0%). 在ACE基因型中:DD (16.0%),DI (48.2%),II (35.8%).
- 在高g耐受性方面,ACTN3和ACE基因型之间的相互作用是显著的 (P < .05).
- ACTN3 RR基因型与耐受性有显著的相关性;ACE DI基因型趋向于显著性 (P = .057). 具有RR+DI基因型的飞行员表现出最高的耐受性.
结论:
- ACTN3 RR基因型与+8.5Gz耐受性显著相关.
- 虽然ACE DI基因型表现出最高的耐受性,但DD基因型的通过率更高,这表明耐受性和测试成功的不同因素.
- 组合的RR+DI基因型与优异的高g耐受性相关,这表明多重基因效应. 身体组成没有显著的相关性.
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