瘤性ASPM是癌症发育和干部信号的监管枢纽
Kelvin K Tsai1,2,3, Byoung-Il Bae4, Chung-Chi Hsu5
1Laboratory of Advanced Molecular Therapeutics, Graduate Institute of Clinical Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.
Cancer research
|June 29, 2023
概括
轴微管组合因子 (ASPM) 异型1驱动癌症的干性和攻击性. 这种蛋白质调节关键的癌症途径和DNA修复,提供了作为生物标志物和治疗点的潜力.
科学领域:
- 在瘤学瘤学.
- 分子生物学分子生物学
- 细胞生物学 细胞生物学
背景情况:
- 晚期癌症缺乏有效的治疗方法,尽管有针对性的疗法和免疫疗法.
- 螺旋微管的组装因子 (ASPM) 是一个中心体蛋白质,参与神经发生和转化.
- 新出现的证据将ASPM,特别是异形1与癌症干细胞性和攻击性联系起来.
研究的目的:
- 审查ASPM在各种癌症中的域组成,转录变异,表达模式和预后意义.
- 总结最近关于ASPM作为癌症发展和癌症发展的监管中心作用的研究结果.
- 突出ASPM的潜力,作为一种癌症不可知预后生物标志物和治疗点.
主要方法:
- 关于ASPM在癌症中的结构,功能和表达的文献综述.
- 分析ASPM参与关键信号通路的情况 (Wnt,刺,Notch).
- 检查ASPM在癌细胞中DNA双链断裂 (DSB) 修复机制中的作用.
主要成果:
- ASPM异型1是多种瘤类型中癌症干性和攻击性的关键调节者.
- ASPM集成了发育和干部信号通路.
- 在癌细胞中,ASPM在DNA双链断裂修复中发挥着重要作用.
结论:
- ASPM,特别是异型1,与癌症的进展和干性有关.
- 在关键的癌症途径和DNA修复中ASPM的参与表明了它的实用性.
- ASPM代表了一个有前途的癌症不可知预后生物标志物和潜在的治疗标.
相关概念视频
Abnormal Proliferation
4.6K
Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
4.6K
mTOR Signaling and Cancer Progression
3.8K
The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
The mTOR pathway or the...
3.8K
Interactions Between Signaling Pathways
6.3K
Signaling cascades usually lack linearity. Multiple pathways interact and regulate one another, allowing cells to integrate and respond to diverse environmental stimuli.
Convergence and divergence, and cross-talk between signaling pathways
Two distinct signaling pathways can converge on a single functional unit, which may either be a single protein or a complex of proteins. The response is either functionally distinct or synergistic between the two pathways but different from the response...
Convergence and divergence, and cross-talk between signaling pathways
Two distinct signaling pathways can converge on a single functional unit, which may either be a single protein or a complex of proteins. The response is either functionally distinct or synergistic between the two pathways but different from the response...
6.3K
Cancer Stem Cells and Tumor Maintenance
5.0K
Early diagnosis and treatment can often cure cancer. However, even with treatment, residual cells called cancer stem cells (CSC) might remain, often causing tumor recurrence. These cancer stem cells possess the potential for self-renewal and multi-lineage differentiation and are often responsible for the therapeutic resistance displayed in most cancers.
Cancer stem cells are thought to originate from tissue-specific normal stem cells or progenitor cells. The normal stem cells usually reside in...
Cancer stem cells are thought to originate from tissue-specific normal stem cells or progenitor cells. The normal stem cells usually reside in...
5.0K
Induced Pluripotent Stem Cells
4.2K
Stem cells are undifferentiated cells that divide and produce different cell types. Ordinarily, cells that have differentiated into a specific cell type are terminally differentiated; however, scientists have found a way to reprogram these mature cells so that they dedifferentiate and return to an unspecialized, proliferative state. These cells are pluripotent like embryonic stem cells—able to produce all cell types—and are called induced pluripotent stem cells (iPSCs).
Somatic...
Somatic...
4.2K
Adaptive Mechanisms in Cancer Cells
5.8K
Cancer cells accumulate genetic changes at an abnormally rapid rate due to the defects in the DNA repair mechanisms. From an evolutionary perspective, such genetic instability is advantageous for cancer development. Mutant cell lines accumulate a series of beneficial mutations that contribute to their progression into cancer.
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...
5.8K


